OX40 Ligand

OX40 Ligand Molekülinformation

Englischer Name	Tumor necrosis factor ligand superfamily member 4	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	13	Target-Alias	CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Englischer Name	Tumor necrosis factor ligand superfamily member 4
Target-Alias	CD134L，OX-40L，TNLG2B，OX4OL，GP34，CD252 Antigen，CD134 Ligand，TAX transcriptionally-activated glycoprotein 1，Tax-Transcriptionally Activated Glycoprotein 1， 34kD，CD252，OX40 ligand，OX40L，TNFSF4，Tumor necrosis factor ligand superfamily member 4，Glycoprotein Gp34，TNF Superfamily Member 4，TXGP1，Tax-Transcriptionally Activated Glycoprotein 1 (34kD)，Tumor Necrosis Factor (Ligand) Superfamily， Member 4，Tumor Necrosis Factor (Ligand) Superfamily Member 4，Tumor Necrosis Factor Superfamily Member 4，Tumor Necrosis Factor Ligand 2B，OX40 Antigen Ligand
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	13
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

OX40 Ligand Produktliste

Attribut
Protein (17)Cell (1)
Produktbibliothek
Online (18)
Spezies
Human (8)Mouse (4)Cynomolgus / Rhesus macaque (3)Rabbit (1)Rat (1)Canine (1)
Etikett
His Tag (8)Mouse IgG Fc Tag (2)Avi Tag & Fc Tag (2)Fc Tag (2)His Tag & Avi Tag (3)- (1)
Marker
Unconjugated (12)Biotin-labeled (5)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT OXL-H5243	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
HOT OXL-H5266	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, Fc Tag, premium grade	In den Warenkorb legen
HOT OXL-H52Q8	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
HOT OXL-H82Q5	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, His,Avitag™, active trimer (MALS verified)	In den Warenkorb legen
CHEK-ATP054	Human	HEK293	HEK293/Human OX40 Ligand Stable Cell Line	In den Warenkorb legen
OXL-H5250	Human	HEK293	Human OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag, low endotoxin	In den Warenkorb legen
OXL-H82F4	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, Avitag™,Fc Tag	In den Warenkorb legen
OXL-H82F5	Human	HEK293	Biotinylated Human OX40 Ligand / TNFSF4 Protein, Fc,Avitag™, premium grade	In den Warenkorb legen
OXL-M5243	Mouse	HEK293	Mouse OX40 Ligand / TNFSF4 Protein, His Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
OXL-M5263	Mouse	HEK293	Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen

Gesamtmenge18

OX40 Ligand Molekülhintergrund

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

OX40 Ligand Molekülalias

OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Amlitelimab	KY-1005; SAR-445229	Phase 3 Clinical	Kymab Ltd, Sanofi	Alopecia Areata; Asthma; Celiac Disease; Dermatitis, Atopic; Eczema; Hidradenitis; Immune System Diseases; Lung Diseases, Interstitial; Scleroderma, Systemic	Details
APG-279	APG279; APG-990/APG777	Phase 2 Clinical	Apogee Therapeutics Inc	Dermatitis, Atopic	Details
IMB-101 (IMBiologics)	IMB-101 (IMBiologics); HDM-3019; IMB101 (IMBiologics); HDM3019; NAV-240	Phase 2 Clinical	IMBiologics Corp	Arthritis, Rheumatoid; Hidradenitis Suppurativa	Details
IBI356	IBI-356; IBI356	Phase 2 Clinical		Autoimmune Diseases; Dermatitis, Atopic	Details
RP-3	RP-3	Phase 2 Clinical	Replimune Inc	Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colorectal Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
HS-130	HS-130	Phase 1 Clinical	Heat Biologics	Solid tumours	Details
mRNA-2752	mRNA-2752	Phase 1 Clinical	Astrazeneca Plc, Moderna Inc	Lymphoma; Neoplasms; Solid tumours	Details
MQ-710	MQ-710	Phase 1 Clinical	Imvaq Therapeutics Corp, Memorial Sloan Kettering Cancer Center	Adenocarcinoma, Sebaceous; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Carcinoma, Squamous Cell; Hemangiosarcoma; Melanoma; Neoplasm Metastasis; Neoplasms; Paget Disease, Extramammary; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details
OX-118	OX-118	Phase 1 Clinical	Oxion Biologics AB	Autoimmune Diseases; Immune System Diseases; Rheumatic Diseases	Details
M-5542	M5542; M-5542	Phase 1 Clinical	Merck & Co Inc		Details
ABCL-575	ABCL-575; ABCL575	Phase 1 Clinical	AbCellera Biologics Inc	Dermatitis, Atopic	Details
APG-990	APG-990; APG990; PR-007; PR007	Phase 1 Clinical	Paragon Therapeutics Inc	Dermatitis, Atopic	Details
SAR-443726	SAR-443726	Phase 1 Clinical	Sanofi	Dermatitis, Atopic	Details