Osteoactivin

Osteoactivin Molekülinformation

Englischer Name	Transmembrane glycoprotein NMB	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Transmembrane glycoprotein NMB
Target-Alias	Transmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Osteoactivin Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
GPB-H5229	Human	HEK293	Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin				In den Warenkorb legen

Gesamtmenge1

Produktanfrage

Osteoactivin Molekülhintergrund

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin Molekülalias

GPNMB,HGFIN,NMB,Osteoactivin

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Glembatumumab vedotin	CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE	Phase 2 Clinical	Celldex Therapeutics	Breast Neoplasms; Carcinoma, Squamous Cell; Melanoma; Osteosarcoma; Skin Melanoma; Solid tumours; Triple Negative Breast Neoplasms; Uveal melanoma	Details
GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta)	GCAR1	Phase 1 Clinical	AHS Cancer Control Alberta	Carcinoma, Renal Cell; Sarcoma; Sarcoma, Alveolar Soft Part; Triple Negative Breast Neoplasms	Details

Produktrezensionen

A***c2026-02-27
0Menschen mögen
Human Osteoactivin / GPNMB Protein, His Tag, low endotoxin
The Human Osteoactivin / GPNMB Protein, His Tag I purchased has been a reliable and useful reagent for interference testing. This reagent was optimal for work in both a PK and ADA assay. There have been no observed lot to lot differences, which is important in my line of work. I would recommend this product.