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Nucleolin

Nucleolin Overview

English Name	Nucleolin	Approved Drugs	1
Drugs in Clinical Trials	4	Target Synonym	NCL，Nucleolin，Protein C23，Nsr1，C23
Highest Development Stage	Approved

English Name	Nucleolin
Target Synonym	NCL，Nucleolin，Protein C23，Nsr1，C23
Approved Drugs	1
Drugs in Clinical Trials	4
Highest Development Stage	Approved

Nucleolin Product List

Product Category
Protein (3)
Product Status
Launched (3)
Species
Human (2)Mouse (1)
Tag
Mouse IgG Fc Tag (2)Fc Tag (1)
Conjugate
Unconjugated (3)

Cat. No.	Species	Host	Product Description
HOT NUL-H5253	Human	HEK293	Human Nucleolin / NCL Protein, Fc Tag
NUL-H5254	Human	HEK293	Human Nucleolin / NCL Protein, Mouse IgG2a Fc Tag
NUL-M5253	Mouse	HEK293	Mouse Nucleolin / NCL Protein, Mouse IgG2a Fc Tag

Total: 3

Nucleolin Background

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Nucleolin Synonyms

Nucleolin,NCL,Protein C23

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
IPP-204106	N6L; Nucant-6L; IPP-204106; IPP-204106N; poyplexed IPP-204106	Phase 2 Clinical	Immupharma Plc	Neoplasms; Solid tumours	Details
AS-1411	AGRO-100; GR-026-B; AS-1411; ACT-GRO-777	Phase 2 Clinical	Antisoma, University Of Alabama At Birmingham, University Of Louisville	Neoplasms; Solid tumours	Details
Pegylated recombinant human endostatin (Tsinghua University)	M-2ES; CRB-0401	Phase 1 Clinical	Beijing Proji Pharmaceutical Technology Co Ltd, Beijing Protgen Biotechnology Development Co Ltd, Tsinghua University	Carcinoma, Non-Small-Cell Lung; Neoplasms; Pancreatic Neoplasms; Solid tumours	Details
APTA-16	APTA-16; SJP1604	Phase 1 Clinical	Aptabio Therapeutics Inc	Leukemia, Myeloid, Acute; Liver Neoplasms; Myelodysplastic Syndromes	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Recombinant human endostatin (Simcere)	YH-16	Approved	Jiangsu Simcere Pharmaceutical Co Ltd	Endostar, 恩度, Endu	Mainland China	Carcinoma, Non-Small-Cell Lung	Shandong Xiansheng Zaiming Biopharmaceutical Co Ltd	2005-09-12	Ascites; Brain metastases; Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Head and Neck Neoplasms; Nasopharyngeal Carcinoma; Osteosarcoma; Pleural Effusion, Malignant	Details