NOTCH2

NOTCH2 Molekülinformation

Englischer Name	Neurogenic locus notch homolog protein 2	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0	Target-Alias	N2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2
Höchste Forschungs- und Entwicklungsphase	Preclinical

Englischer Name	Neurogenic locus notch homolog protein 2
Target-Alias	N2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0
Höchste Forschungs- und Entwicklungsphase	Preclinical

NOTCH2 Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
Fc Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
NO2-H5255	Human	HEK293	Human NOTCH2 Protein, Fc Tag (MALS verified)				In den Warenkorb legen

Gesamtmenge1

NOTCH2 Molekülhintergrund

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .