Melanotransferrin
Melanotransferrin Molekülinformation
| Englischer Name | Melanotransferrin | Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 | Target-Alias | Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2 |
| Höchste Forschungs- und Entwicklungsphase | Phase 1 Clinical | ||
| Englischer Name | Melanotransferrin |
| Target-Alias | Melanoma-associated antigen p97，CD228，Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5，MAP97，Membrane-Bound Transferrin-Like Protein，MGC4856，MTF1，FLJ38863，CD228 Antigen，MTf，MFI2 |
| Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 |
| Höchste Forschungs- und Entwicklungsphase | Phase 1 Clinical |
Melanotransferrin Produktliste
- Attribut
Protein (2)
- Produktbibliothek
Online (2)
- Spezies
Human (1)Cynomolgus (1)
- Etikett
His Tag (2)
- Marker
Unconjugated (2)
| Produktnummer | Spezies | Expressionssystem | Produktbeschreibung | Proteinstruktur | Reinheit | Eigenschaften | Vorbestellen/Bestellen |
|---|---|---|---|---|---|---|---|
 Human | HEK293 | Human Melanotransferrin / CD228 Protein, His Tag (MALS verified) |  |  |  In den Warenkorb legen | ||
 Cynomolgus | HEK293 | Cynomolgus Melanotransferrin / CD228 Protein, His Tag, low Endotoxin (MALS verified) |  | |  | In den Warenkorb legen |
Gesamtmenge2
- 1
Melanotransferrin Molekülhintergrund
Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).
Melanotransferrin Molekülalias
Melanotransferrin,CD228,MFI2,MAP97,MELTF
Klinische Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Indikationen | Klinische Studie |
|---|---|---|---|---|---|
| BA-1302 | BA-1302; BA1302 | Phase 1 Clinical | Shandong Boan Biotechnology Co Ltd | Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Pancreatic Neoplasms; Solid tumours | Details |
| SGN-BB228 | SGN-BB228; PF-08046049; BB-228; PRS-346 | Phase 1 Clinical | Pieris Pharmaceuticals | Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Melanoma; Mesothelioma; Pancreatic Neoplasms; Skin Melanoma; Solid tumours | Details |
- Molekülinformation
- Produktliste
- Klinische Arzneimittelinformation