MCAM

MCAM Molekülinformation

Englischer Name	Melanoma cell adhesion molecule	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Melanoma cell adhesion molecule
Target-Alias	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

MCAM Produktliste

Attribut
Protein (3)Cell (1)
Produktbibliothek
Online (4)
Spezies
Human (3)Mouse (1)
Etikett
His Tag (2)- (1)His Tag & Avi Tag (1)
Marker
Unconjugated (2)- (1)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CD6-H5229	Human	HEK293	Human MCAM / CD146 Protein, His Tag	In den Warenkorb legen
CHEK-ATP195	Human	HEK293	HEK293/Human MCAM Stable Cell Line	In den Warenkorb legen
MCM-H82E3	Human	HEK293	Biotinylated Human MCAM / CD146 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
MCM-M52H3	Mouse	HEK293	Mouse MCAM / CD146 Protein, His Tag	In den Warenkorb legen

Gesamtmenge4

MCAM Molekülhintergrund

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM Molekülalias

MCAM,CD146,MUC18

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
CD146 targeting CAR-T cell therapy (Essen Biotech)		Phase 2 Clinical	Essen Biotech	Carcinoma, Ovarian Epithelial; Osteosarcoma; Ovarian Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial	Details
AMT-253(Multitude)	AMT-253; AMT-253 ADC	Phase 2 Clinical	Multitude Therapeutics Inc	Melanoma; Solid tumours	Details