MAdCAM-1

MAdCAM-1 Molekülinformation

Englischer Name	Mucosal addressin cell adhesion molecule-1	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	4	Target-Alias	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Mucosal addressin cell adhesion molecule-1
Target-Alias	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	4
Höchste Forschungs- und Entwicklungsphase	Approved

MAdCAM-1 Produktliste

Attribut
Protein (7)Cell (1)
Produktbibliothek
Online (8)
Spezies
Human (4)Cynomolgus (2)Mouse (2)
Etikett
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag (3)His Tag & Avi Tag (2)- (1)
Marker
Unconjugated (4)Biotin-labeled (3)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT MAM-H5253	Human	HEK293	Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)	In den Warenkorb legen
HOT MAM-H52H4	Human	HEK293	Human MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)	In den Warenkorb legen
HOT MAM-H8251	Human	HEK293	Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)	In den Warenkorb legen
CCHO-ATP241	Human	CHO	CHO/Human MAdCAM-1 Stable Cell Line	In den Warenkorb legen
MAM-M52H3	Mouse	HEK293	Mouse MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)	In den Warenkorb legen
MAM-M82E3	Mouse	HEK293	Biotinylated Mouse MAdCAM-1 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
MAM-C52H3	Cynomolgus	HEK293	Cynomolgus MAdCAM-1 Protein, His Tag, low endotoxin	In den Warenkorb legen
MAM-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus MAdCAM-1 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen

Gesamtmenge8

MAdCAM-1 Molekülhintergrund

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

MAdCAM-1 Molekülalias

MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis	Details
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	Details
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	Details
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	Details