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MAdCAM-1

MAdCAM-1 Overview

English Name	Mucosal addressin cell adhesion molecule-1	Approved Drugs	1
Drugs in Clinical Trials	4	Target Synonym	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Highest Development Stage	Approved

English Name	Mucosal addressin cell adhesion molecule-1
Target Synonym	Mucosal addressin cell adhesion molecule 1，MADCAM1，hMAdCAM-1，Mucosal Vascular Addressin Cell Adhesion Molecule 1，MACAM1，MAdCAM-1，Mucosal Addressin Cell Adhesion Molecule-1
Approved Drugs	1
Drugs in Clinical Trials	4
Highest Development Stage	Approved

MAdCAM-1 Product List

Product Category
Protein (7)Cell (1)
Product Status
Launched (8)
Species
Human (4)Cynomolgus (2)Mouse (2)
Tag
Fc Tag (1)Fc Tag & Avi Tag (1)His Tag (3)His Tag & Avi Tag (2)- (1)
Conjugate
Unconjugated (4)Biotin-labeled (3)- (1)

Cat. No.	Species	Host	Product Description
HOT MAM-H5253	Human	HEK293	Human MAdCAM-1 Protein, Fc Tag, low endotoxin (MALS verified)
HOT MAM-H52H4	Human	HEK293	Human MAdCAM-1 Protein, His Tag (MALS & SPR verified)
HOT MAM-H8251	Human	HEK293	Biotinylated Human MAdCAM-1 Protein, Fc,Avitag™ (MALS verified)
CCHO-ATP241	Human	CHO	CHO/Human MAdCAM-1 Stable Cell Line
MAM-M52H3	Mouse	HEK293	Mouse MAdCAM-1 Protein, His Tag, low endotoxin (MALS & SPR verified)
MAM-M82E3	Mouse	HEK293	Biotinylated Mouse MAdCAM-1 Protein, His,Avitag™ (MALS verified)
MAM-C52H3	Cynomolgus	HEK293	Cynomolgus MAdCAM-1 Protein, His Tag, low endotoxin
MAM-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus MAdCAM-1 Protein, His,Avitag™ (MALS verified)

Total: 8

MAdCAM-1 Background

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

MAdCAM-1 Synonyms

MAdCAM-1,MAdCAM1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Colitis, Ulcerative; Crohn Disease; Fatty Liver; Ileitis	Details
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Colitis, Ulcerative; Crohn Disease; Pouchitis	Details
Vedolizumab Biosimilar (Intas Pharmaceuticals)	INTP-53; INTP53	Phase 3 Clinical	Intas Pharmaceuticals Ltd	Colitis, Ulcerative	Details
Vedolizumab biosimilar (Alvotech)	AVT-16; AVT16	Phase 1 Clinical	Alvotech Swiss Ag	Colitis, Ulcerative; Immune System Diseases	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	Entyvio, Entyvio Pen, Kynteles, 安吉优	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Carcinoma, Non-Small-Cell Lung; Celiac Disease; Cholangitis, Sclerosing; Colitis; Colitis, Ulcerative; Crohn Disease; Gastritis; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Inflammatory Bowel Diseases; Melanoma; Neoplasms; Pediatric Crohn's disease; Pediatric ulcerative colitis; Pouchitis; Solid tumours; Urogenital Neoplasms	Details