LRP-6

LRP-6 Molekülinformation

Englischer Name	Low-density lipoprotein receptor-related protein 6	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0	Target-Alias	LDL Receptor Related Protein 6，LRP6
Höchste Forschungs- und Entwicklungsphase	Preclinical

Englischer Name	Low-density lipoprotein receptor-related protein 6
Target-Alias	LDL Receptor Related Protein 6，LRP6
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0
Höchste Forschungs- und Entwicklungsphase	Preclinical

LRP-6 Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (2)
Etikett
Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)
Marker
Unconjugated (1)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
LR6-H5253	Human	HEK293	Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag				In den Warenkorb legen
LR6-H82E7	Human	HEK293	Biotinylated Human LRP-6 (20-630) Protein, His,Avitag™				In den Warenkorb legen

Gesamtmenge2

LRP-6 Molekülhintergrund

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.