LOXL2

LOXL2 Molekülinformation

Englischer Name	Lysyl oxidase homolog 2	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Lysyl oxidase homolog 2
Target-Alias	EC:1.4.3.13，EC 1.4.3，Lysyl oxidase-like protein 2，Lysyl oxidase homolog 2，LOXL2，Lysyl Oxidase Like 2，Lysyl Oxidase-Related Protein WS9-14，Lysyl Oxidase-Related Protein 2，Lysyl Oxidase-Like 2 Delta E13，Lysyl Oxidase-Like 2 Protein，Lysyl Oxidase Related 2，Lysyl Oxidase-Like 2，EC 1.4.3.13，WS9-14，LOR2，LOR
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

LOXL2 Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (2)
Etikett
His Tag & Avi Tag (1)His Tag (1)
Marker
Biotin-labeled (1)Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
LO2-H52H3	Human	HEK293	Human LOXL2 Protein, His Tag (active enzyme)				In den Warenkorb legen
LO2-H82E3	Human	HEK293	Biotinylated Human LOXL2 Protein, His,Avitag™ (active enzyme)				In den Warenkorb legen

Gesamtmenge2

LOXL2 Molekülhintergrund

Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.