LIGHT

LIGHT Molekülinformation

Englischer Name	Tumor necrosis factor superfamily member 14	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Tumor necrosis factor superfamily member 14
Target-Alias	CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

LIGHT Produktliste

Attribut
Protein (6)Cell (1)
Produktbibliothek
Online (7)
Spezies
Human (5)Cynomolgus (1)Mouse (1)
Etikett
Mouse IgG Fc Tag (1)His Tag (4)Fc Tag (1)- (1)
Marker
Unconjugated (6)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT LIT-H5242	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
HOT LIT-H5269	Human	HEK293	Human LIGHT / TNFSF14 Protein, Fc Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
HOT LIT-M5243	Mouse	HEK293	Mouse LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)	In den Warenkorb legen
HOT LIT-C5244	Cynomolgus	HEK293	Cynomolgus LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)	In den Warenkorb legen
LIT-H5243	Human	HEK293	Human LIGHT / TNFSF14 Protein, His Tag, Ultra Low Endotoxin (MALS verified)	In den Warenkorb legen
LIT-H5256	Human	HEK293	Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin	In den Warenkorb legen
SCCHO-ATP109	Human	CHO	CHO/Human LIGHT Stable Cell Line	In den Warenkorb legen

Gesamtmenge7

LIGHT Molekülhintergrund

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

LIGHT Molekülalias

CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Quisovalimab	CERC-002; AEVI-002; MDGN-002; SAR-252067; AVTX-002	Phase 2 Clinical	Kyowa Hakko Kirin Co Ltd, La Jolla Pharmaceutical Company	Acute Lung Injury; Asthma; Colitis, Ulcerative; Coronavirus Disease 2019 (COVID-19); Crohn Disease; Respiratory Distress Syndrome, Adult	Details

Produktrezensionen

E***a2021-09-23
1Menschen mögen
Human LIGHT / TNFSF14 Protein, His Tag, active trimer, low endotoxin (MALS verified)
We use this protein as an ELISA standard. We are interested in quantifying soluble LIGHT concentration from human serum. This active form of the protein perfectly binds its receptors and policlonal antibodies. The standard curve obtained is highly reproducible. It was very easy to find all the information in the web of AcroBiosystems and to download the CoA, which was also very descriptive.