LIGHT Molekülinformation
Molecule Name
Tumor necrosis factor superfamily member 14
Molekülalias
CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML
Drug Development Progress
Anzahl der klinischen Arzneimittel1
Anzahl der inverkehr gebrachten Arzneimittel0
Höchste Forschungs- und EntwicklungsphasePhase 2 Clinical
Target-Alias
CD258 Antigen，Herpes Virus Entry Mediator Ligand，TNFSF14，Herpesvirus Entry Mediator Ligand，LIGHT，Tumor Necrosis Factor (Ligand) Superfamily， Member 14，CD258，HVEM-L，Tumor Necrosis Factor Ligand 1D，LTg，HVEML，TNF Superfamily Member 14，Tumor Necrosis Factor Ligand Superfamily Member 14，Tumor Necrosis Factor Superfamily Member 14
Molekülhintergrund
Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
LIGHT Produktliste
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E***a2021-09-23We use this protein as an ELISA standard. We are interested in quantifying soluble LIGHT concentration from human serum. This active form of the protein perfectly binds its receptors and policlonal antibodies. The standard curve obtained is highly reproducible. It was very easy to find all the information in the web of AcroBiosystems and to download the CoA, which was also very descriptive.