LGR5

LGR5 Molekülinformation

Englischer Name	Leucine-rich repeat-containing G-protein coupled receptor 5	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Leucine-rich repeat-containing G-protein coupled receptor 5
Target-Alias	FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

LGR5 Produktliste

Attribut
Protein (4)Cell (1)
Produktbibliothek
Online (5)
Spezies
Human (4)Cynomolgus (1)
Etikett
His Tag (2)Fc Tag (1)His Tag & Avi Tag (1)- (1)
Marker
Unconjugated (3)Biotin-labeled (1)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CHEK-ATP327	Human	HEK293	HEK293/Human LGR5 Stable Cell Line	In den Warenkorb legen
LG5-H5253	Human	HEK293	Human LGR5 / GPR49 protein, Fc Tag	In den Warenkorb legen
LG5-H52H3	Human	HEK293	Human LGR5 / GPR49 Protein, His Tag, low endotoxin	In den Warenkorb legen
LG5-H82E4	Human	HEK293	Biotinylated Human LGR5 / GPR49 (22-561) Protein, His,Avitag™	In den Warenkorb legen
LG5-C52H7	Cynomolgus	HEK293	Cynomolgus LGR5 / GPR49 protein, His Tag	In den Warenkorb legen

Gesamtmenge5

LGR5 Molekülhintergrund

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5 Molekülalias

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Petosemtamab	MCLA-158	Phase 2 Clinical	Merus Nv	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	Details
CNA-3103	CNA-3103	Phase 2 Clinical	Carina Biotech Pty Ltd	Colorectal Neoplasms	Details