Leptin R

Leptin R Molekülinformation

Englischer Name	Leptin receptor	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	3	Target-Alias	CD295，OB receptor，LEPR，HuB219，DB，Leptin Receptor，LEP-R，OB-R，OBR，CD295 Antigen，LEPRD，Receptors， Leptin
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Leptin receptor
Target-Alias	CD295，OB receptor，LEPR，HuB219，DB，Leptin Receptor，LEP-R，OB-R，OBR，CD295 Antigen，LEPRD，Receptors， Leptin
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	3
Höchste Forschungs- und Entwicklungsphase	Approved

Leptin R Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (2)
Etikett
Fc Tag (1)His Tag & Avi Tag (1)
Marker
Unconjugated (1)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
LER-H5252	Human	HEK293	Human Leptin R / CD295 Protein, Fc Tag				In den Warenkorb legen
LER-H82E3	Human	HEK293	Biotinylated Human Leptin R Protein, His,Avitag™				In den Warenkorb legen

Gesamtmenge2

Leptin R Molekülhintergrund

Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

Leptin R Molekülalias

LEPR,CD295,DKFZp686B1731,OBR,Leptin receptor

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Mibavademab	REGN-4461	Phase 3 Clinical	Regeneron Pharmaceuticals Inc	Amenorrhea; Lipodystrophy, Congenital Generalized; Lipodystrophy, Familial Partial; Monogenic obesity; Obesity	Details
RG-6436	RG6436; RG-6436	Phase 1 Clinical	Enterprise Therapeutics Ltd, Genentech Inc	Urinary Tract Infections	Details
ERX-1000	ERX-1000	Phase 1 Clinical	ERX Pharmaceuticals Inc	Obesity	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Metreleptin	KTR-103; AC-164594	Approved	Amylin Pharmaceutical, Astrazeneca Plc, Bristol-Myers Squibb Company	Metreleptin [SHIONOGI], Myalepta	Japan	Lipodystrophy	Shionogi & Co Ltd	2013-03-25	Diabetes Mellitus; Diabetes Mellitus, Type 1; HIV Infections; Hyperlipidemias; Insulin Resistance; Lipodystrophy; Lipodystrophy, Congenital Generalized; Lipodystrophy, Familial Partial; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight	Details