KLRG1

KLRG1 Molekülinformation

Englischer Name	Killer cell lectin-like receptor subfamily G member 1	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Englischer Name	Killer cell lectin-like receptor subfamily G member 1
Target-Alias	C-type lectin domain family 15 member A，ITIM-containing receptor MAFA-L，MAFA-like receptor，Mast cell function-associated antigen，CLEC15A，MAFA，MAFAL
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

KLRG1 Produktliste

Attribut
Protein (5)
Produktbibliothek
Online (5)
Spezies
Human (1)Mouse (1)Cynomolgus (3)
Etikett
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
Marker
Unconjugated (4)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT KL1-H5249	Human	HEK293	Human KLRG1 Protein, His Tag	In den Warenkorb legen
HOT KL1-M5249	Mouse	HEK293	Mouse KLRG1 Protein, His Tag (MALS & SPR verified)	In den Warenkorb legen
HOT KL1-C5243	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, His Tag (SPR verified)	In den Warenkorb legen
HOT KL1-C5269	Cynomolgus	HEK293	Cynomolgus KLRG1 Protein, Fc Tag (SPR verified)	In den Warenkorb legen
KL1-C82Q4	Cynomolgus	HEK293	Biotinylated Cynomolgus KLRG1 Protein, Avitag™,His Tag	In den Warenkorb legen

Gesamtmenge5

KLRG1 Molekülhintergrund

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.