Kallikrein 12

Kallikrein 12 (KLK12) is a member of the human tissue kallikrein-related peptidase family, located on chromosome 19q13.41. It encodes a secreted serine protease of about 261 amino acids with a molecular weight of ~30 kDa. KLK12 is expressed at high levels in the prostate and also detectable in tissues such as kidney and stomach. Functionally, KLK12 participates in extracellular matrix degradation and remodeling, influencing cell proliferation, differentiation, and signaling.