ILDR2

ILDR2 Molekülinformation

Englischer Name	Immunoglobulin-like domain-containing receptor 2	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Immunoglobulin-like domain-containing receptor 2
Target-Alias	Immunoglobulin-like domain-containing receptor 2，ILDR2，C1orf32，Immunoglobulin-Like Domain Containing Receptor 2，LISCH-Like，DJ782G3.1，Immunoglobulin Like Domain Containing Receptor 2，Chromosome 1 Open Reading Frame 32
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

ILDR2 Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
Fc Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
IL2-H5259	Human	HEK293	Human ILDR2 Protein, Fc Tag				In den Warenkorb legen

Gesamtmenge1

ILDR2 Molekülhintergrund

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.