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Home PageAll MoleculesIL-7 R alpha & TSLP R
IL-7 R alpha & TSLP R
IL-7 R alpha & TSLP R Overview
| English Name | Interleukin-7 receptor subunit alpha | Approved Drugs | 0 |
| Drugs in Clinical Trials | 8 | Target Synonym | Interleukin-7 receptor subunit alpha，Interleukin 7 Receptor Isoform H5-6，CDw127，IL-7R subunit alpha，IL-7RA，IL-7 receptor subunit alpha，CD127 Antigen，IL-7R-Alpha，Interleukin 7 Receptor Alpha Chain，CD127，IL7RA，ILRA，Interleukin-7 Receptor alpha Subunit |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Interleukin-7 receptor subunit alpha |
| Target Synonym | Interleukin-7 receptor subunit alpha，Interleukin 7 Receptor Isoform H5-6，CDw127，IL-7R subunit alpha，IL-7RA，IL-7 receptor subunit alpha，CD127 Antigen，IL-7R-Alpha，Interleukin 7 Receptor Alpha Chain，CD127，IL7RA，ILRA，Interleukin-7 Receptor alpha Subunit |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 8 |
| Highest Development Stage | Phase 2 Clinical |
IL-7 R alpha & TSLP R Product List
- Product Category
Protein (3)Cell (1)Kits (1)
- Product Status
Launched (5)
- Species
Human (4)Mouse (1)
- Tag
Fc Tag (3)- (2)
- Conjugate
Unconjugated (3)- (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CHEK-ATF045 |  Human | HEK293 | Human TSLP R (Luc) HEK293 Reporter Cell |  | ||
HOT EP-129 | Human | - | TSLP [Biotinylated] : IL-7Rα & TSLP R Inhibitor Screening ELISA Kit | |||
HOT ILR-H5255 | Human | HEK293 | Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag, low endotoxin (MALS verified) |  |  |  |
ILR-H525x | Human | HEK293 | Human IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag |  | | |
ILR-M5257 |  Mouse | HEK293 | Mouse IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag |  | | |
Total: 5
- 1
IL-7 R alpha & TSLP R Background
TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
IL-7 R alpha & TSLP R Synonyms
IL7Ra,CD127,TSLP R,CRLF2,IL-XR,ILXR,p2RY8,CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| CYT-107 | CYT-107; CYT-99-007; rhIL-7 | Phase 2 Clinical | Revimmune Inc | Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Catheter-Related Infections; Coronavirus Disease 2019 (COVID-19); Hepatitis B, Chronic; Hepatitis C; HIV Infections; Kidney Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Acute; Lymphopenia; Metastatic breast cancer; Multiple Myeloma; Mycobacterium Infections, Nontuberculous; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Sarcoma, Kaposi; Sepsis; Shock, Septic; Skin Melanoma; T-Lymphocytopenia, Idiopathic CD4-Positive; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms | Details |
| Lusvertikimab | OSE-127; S-95011; Effi-7; OSE-217 | Phase 2 Clinical | Effimune | Colitis, Ulcerative; Sjogren's Syndrome | Details |
| Efineptakin alfa | TJ-107; GX-I7; NT-I7 | Phase 2 Clinical | Gannex Pharma Co Ltd | Astrocytoma; Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Coronavirus Disease 2019 (COVID-19); Esophageal Neoplasms; Glioblastoma; Glioma; Gliosarcoma; HIV Infections; Hypopharyngeal Neoplasms; Laryngeal Neoplasms; Leukoencephalopathy, Progressive Multifocal; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphopenia; Melanoma; Multiple Myeloma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Papillomavirus Infections; Plasmablastic Lymphoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms | Details |
| ASP-9801 | ASP-9801 | Phase 1 Clinical | Astellas Pharma Inc | Neoplasm Metastasis; Neoplasms; Solid tumours | Details |
| PF-06342674 | RN-168; PF-6342674; PF-06342674; ZB-168 | Phase 1 Clinical | Pfizer Inc | Diabetes Mellitus, Type 1; Multiple Sclerosis | Details |
| CD19-IL7Ra CAR-T cells therapy (Chulalongkorn University) | CMD-63; CMD63 | Phase 1 Clinical | Chulalongkorn University | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | Details |
| Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University) | Phase 1 Clinical | Chulalongkorn University, King Chulalongkorn Memorial Hospital | Brain Neoplasms; Diffuse Intrinsic Pontine Glioma; Neoplasms; Solid tumours | Details | |
| MDK-703 | MDK-703 | Phase 1 Clinical | Medikine Inc | Solid tumours | Details |
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