IL-31

IL-31 Molekülinformation

Englischer Name	Interleukin-31	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5	Target-Alias	Interleukin 31，IL-31
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Interleukin-31
Target-Alias	Interleukin 31，IL-31
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

IL-31 Produktliste

Attribut
Protein (8)Kits (1)
Produktbibliothek
Online (9)
Spezies
Human (4)Cynomolgus (3)Mouse (2)
Etikett
His Tag (4)His Tag & Avi Tag (3)Tag Free (1)- (1)
Marker
Unconjugated (5)Biotin-labeled (3)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT IL1-H5219	Human	HEK293	Human IL-31 Protein, premium grade	In den Warenkorb legen
HOT IL1-H5247	Human	HEK293	Human IL-31 Protein, His Tag, low Endotoxin (MALS verified)	In den Warenkorb legen
HOT IL1-C5245	Cynomolgus	HEK293	Cynomolgus IL-31 Protein, His Tag, low endotoxin	In den Warenkorb legen
CEA-C243	Human	-	Human IL-31 ELISA Kit	In den Warenkorb legen
IL1-H82E6	Human	HEK293	Biotinylated Human IL-31 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
IL1-M5244	Mouse	HEK293	Mouse IL-31 Protein, His Tag (HPLC verified)	In den Warenkorb legen
IL1-M82Q9	Mouse	HEK293	Biotinylated Mouse IL-31 Protein, His,Avitag™ (MALS & BLI verified)	In den Warenkorb legen
IL1-C52H3	Cynomolgus	HEK293	Cynomolgus IL-31 Protein, His Tag, ultra low endotoxin (MALS verified)	In den Warenkorb legen
IL1-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus IL-31 Protein, His,Avitag™ (HPLC verified)	In den Warenkorb legen

Gesamtmenge9

IL-31 Molekülhintergrund

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.

IL-31 Molekülalias

IL-31,IL31,Interleukin-31

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
JNJ-5939	JNJ-5939; NM-26; NM26-2198; JNJ-95475939	Phase 2 Clinical	Numab Therapeutics Ag	Dermatitis, Atopic; Inflammation	Details
ATTO-3712	ATTO-3712	Phase 1 Clinical	Attovia Therapeutics Inc	Dermatitis, Atopic; Pruritus	Details
BBT-001	BBT001; BBT-001	Phase 1 Clinical	Bambusa Therapeutics Inc	Dermatitis, Atopic	Details
ZL-1503	ZL-1503	Phase 1 Clinical	Zai Lab Ltd	Dermatitis, Atopic	Details
ATTO-1310	ATTO-1310	Phase 1 Clinical	Attovia Therapeutics Inc	Dermatitis, Atopic; Pruritus	Details