IL-11 R alpha Overview
Molecule Name
Interleukin 11 receptor alpha
Synonyms
IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha
Drug Development Progress
Drugs in Clinical Trials3
Approved Drugs9
Highest Development StageApproved
Target Synonym
Interleukin-11 Receptor Alpha Chain，Interleukin 11 Receptor Subunit Alpha，Interleukin 11 Receptor， Alpha，IL-11R-Alpha，IL-11 Receptor Subunit Alpha，Interleukin-11 Receptor Subunit Alpha，IL11RA，IL-11RA，IL-11R Subunit Alpha，CRSDA，Interleukin-11 Receptor alpha Subunit，sIL-11RA，sIL-11R，sIL11RA
Background
Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
IL-11 R alpha Product List
You Have Viewed 0 Of 0 Results
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Δ1-9, alanine 10, asparagine 134, recombinant human interleukin-11 | Phase 3 Clinical | Fuzhou Quanye Economic Technology Co Ltd | Thrombocytopenia | Details | |
| LASN-01 | LASN-01 | Phase 2 Clinical | Csl Ltd | Endocrine System Diseases; Exophthalmos; Eye Diseases; Graves Ophthalmopathy; Pulmonary Fibrosis | Details |
| NMX-1 | NMX-1 | Phase 2 Clinical | Novomedix LLC | Triple Negative Breast Neoplasms | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Oprelvekin biosimilar (Hangzhou Jiuyuan Gene Engineering) | Approved | Hangzhou Jiuyuan Gene Biomedical Co Ltd | 吉巨芬, Jijufen | Mainland China | Thrombocytopenia | Hangzhou Jiuyuan Gene Biomedical Co Ltd | 2003-09-18 | Thrombocytopenia | Details | |
| Recombinant human interleukin-11 (Qilu Pharmaceutical) | Approved | Qilu Pharmaceutical Co Ltd | 巨和粒 | Mainland China | Thrombocytopenia | Qilu Pharmaceutical Co Ltd | 2003-03-18 | Thrombocytopenia | Details | |
| Recombinant human interleukin-11 (Kerun Biopharmaceutical) | Approved | Chongqing Kerun Biologic Pharmaceutical Development Co Ltd | 百杰依 | Mainland China | Thrombocytopenia | China Resources Angde Biotech Pharma Co Ltd | 2008-05-08 | Thrombocytopenia | Details | |
| Recombinant human interleukin-11 (Beijing ShuangLu Pharmaceutical) | Approved | Beijing Sl Pharmaceutical Co Ltd | 迈格尔 | Mainland China | Thrombocytopenia | Beijing Sl Pharmaceutical Co Ltd | 2003-03-17 | Thrombocytopenia | Details | |
| Recombinant human interleukin-11 (Xiamen Amoytop Biotech) | rHuIL-11 | Approved | Xiamen Amoytop Biotech Co Ltd | 特尔康 | Mainland China | Thrombocytopenia | Xiamen Amoytop Biotech Co Ltd | 2005-04-11 | Thrombocytopenia | Details |
| Recombinant human interleukin 11 (BioGeneric Pharma) | Approved | Biogeneic Pharma | Thrombocytopenia | Details | ||||||
| Recombinant human interleukin-11 for injection | Approved | Details | ||||||||
| Recombinant human interleukin-11 (Shanghai CP Guojian) | Approved | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | 欣美格 | Mainland China | Thrombocytopenia | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | 2005-04-26 | Thrombocytopenia | Details | |
| Recombinant human interleukin-11 (Diao group) | Approved | Chengdu Diao Jiuhong Pharmaceutical Factory | 依星 | Mainland China | Thrombocytopenia | Chengdu Diao Jiuhong Pharmaceutical Factory | 2003-04-23 | Thrombocytopenia | Details |