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IL-1 Rrp2

IL-1 Rrp2 Overview

English Name	Interleukin-36 receptor	Approved Drugs	1
Drugs in Clinical Trials	4	Target Synonym	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
Highest Development Stage	Approved

English Name	Interleukin-36 receptor
Target Synonym	Interleukin-1 Receptor-Related Protein 2，Interleukin-1 Receptor-Like 2，IL-1Rrp2，Interleukin 1 Receptor Like 2，EC:3.2.2.6，IL-36R，IL1RRP2，IL-36 Receptor，IL1R-Rp2，IL1RL2，IL-1 Receptor-Related Protein 2
Approved Drugs	1
Drugs in Clinical Trials	4
Highest Development Stage	Approved

IL-1 Rrp2 Product List

Product Category
Protein (5)
Product Status
Launched (5)
Species
Human (4)Cynomolgus (1)
Tag
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (4)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HOT IL2-H5254	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, Fc Tag
HOT IL2-H52H4	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 (C154S, C262S) Protein, His Tag (MALS verified)
HOT IL2-H52H6	Human	HEK293	Human IL-1 Rrp2 / IL-1 R6 Protein, His Tag, low endotoxin
HOT IL2-H82E9	Human	HEK293	Biotinylated Human IL-1 Rrp2 / IL-1 R6 Protein, His,Avitag™
HOT IL2-C52H5	Cynomolgus	HEK293	Cynomolgus IL-1 Rrp2 / IL-1 R6 Protein, His Tag

Total: 5

IL-1 Rrp2 Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL‑1 R3), ST2 (T1/IL-1 R4), IL-18 Ra (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL-18 Rb (AcPL/IL-1 R7), IL-1RAPL‑1 (TIGIRR‑2/IL‑1 R8), and TIGIRR-1 (IL-1 R9). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL-18BP, differ from the other members by having only one Ig domain.

IL-1 Rrp2 Synonyms

IL-1 R6,IL-1 Rrp2,IL1RL2,IL-1RL2,IL1Rrp2,IL-1Rrp2,IL1RRP2,IL-36R

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
HB-0043	HB-0043	Phase 2 Clinical	HuaBo Biopharm Co Ltd	Acne Vulgaris; Arthritis, Rheumatoid; Autoimmune Diseases; Dermatitis, Atopic; Hidradenitis Suppurativa; Lupus Erythematosus, Systemic; Lupus Nephritis; Psoriasis; Renal Insufficiency, Chronic	Details
SHR-1139	SHR1139; SHR-1139	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Colitis, Ulcerative; Plaque psoriasis; Psoriasis; Pyoderma Gangrenosum	Details
TQH-2929	TQH-2929; TQH2929	Phase 2 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Generalised pustular psoriasis; Psoriasis; Pustular psoriasis	Details
IMG-008	IMG008	Phase 1 Clinical	Ikena Oncology Inc	Autoimmune Diseases; Inflammation	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Spesolimab	BI-655130	Approved	C.H. Boehringer Sohn Ag & Co. Kg	圣利卓, Spevigo	United States	Psoriasis	Boehringer Ingelheim Pharmaceuticals Inc	2022-09-01	Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Generalised pustular psoriasis; Hidradenitis Suppurativa; Netherton Syndrome; Palmoplantar pustulosis; Psoriasis; Pyoderma Gangrenosum	Details