HVEM

HVEM Molekülinformation

Englischer Name	Tumor necrosis factor receptor superfamily member 14	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0	Target-Alias	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Höchste Forschungs- und Entwicklungsphase	Preclinical

Englischer Name	Tumor necrosis factor receptor superfamily member 14
Target-Alias	Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	0
Höchste Forschungs- und Entwicklungsphase	Preclinical

HVEM Produktliste

Attribut
Protein (4)Cell (3)
Produktbibliothek
Online (7)
Spezies
Human (7)
Etikett
Fc Tag (1)His Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)- (3)
Marker
Unconjugated (3)Biotin-labeled (1)- (3)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT HVM-H5257	Human	HEK293	Human HVEM / TNFRSF14 Protein, Mouse IgG2a Fc Tag (MALS verified)	In den Warenkorb legen
HOT HVM-H5258	Human	HEK293	Human HVEM / TNFRSF14 Protein, Fc Tag, low endotoxin (MALS verified)	In den Warenkorb legen
HOT HVM-H52E9	Human	HEK293	Human HVEM / TNFRSF14 Protein, His Tag (MALS verified)	In den Warenkorb legen
HOT HVM-H82F6	Human	HEK293	Biotinylated Human HVEM / TNFRSF14 Protein, Fc,Avitag™ (MALS verified)	In den Warenkorb legen
CHEK-ATF105	Human	HEK293	Human HVEM (Luc) HEK293 Reporter Cell	In den Warenkorb legen
CHEK-ATP147	Human	HEK293	HEK293/Human HVEM Stable Cell Line	In den Warenkorb legen
SCRAJ-STF108	Human	Raji	Raji/Human HVEM Stable Cell Line	In den Warenkorb legen

Gesamtmenge7

HVEM Molekülhintergrund

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.