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HMGB1

HMGB1 Overview

English Name	High Mobility Group Protein B1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
Highest Development Stage	Phase 2 Clinical

English Name	High Mobility Group Protein B1
Target Synonym	FM1 Gene Product，HMG 1 Protein，HMG-1 Protein，HMG1，Heparin-Binding Protein p30，High Mobility Group Box 1，High-Mobility Group (Nonhistone Chromosomal) Protein 1，High Mobility Group Protein B1，High Mobility Group Protein 1，HMG-1，Sulfoglucuronyl Carbohydrate Binding Protein，Amphoterin，Box Protein 1， High Mobility Group，SBP-1，High-Mobility Group Box 1，DKFZp686A04236，HMGB1
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

HMGB1 Product List

Product Category
Protein (4)
Product Status
Launched (4)
Species
Human (3)Mouse (1)
Tag
His Tag (2)Mouse IgG Fc Tag (1)His Tag & Avi Tag (1)
Conjugate
Unconjugated (3)Biotin-labeled (1)

Cat. No.	Species	Host	Product Description
HM1-H5220	Human	HEK293	Human HMGB1 Protein, His Tag, low endotoxin
HM1-H5255	Human	HEK293	Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
HM1-H82E3	Human	HEK293	Biotinylated Human HMGB1 Protein, His,Avitag™
HM1-M52H6	Mouse	HEK293	Mouse HMGB1 Protein, His Tag (MALS verified)

Total: 4

HMGB1 Background

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

HMGB1 Synonyms

HMGB1,HMG1,HMG3,SBP-1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
SB-17170	SB-17170	Phase 2 Clinical	Spark Biopharma Inc	Drug-Related Side Effects and Adverse Reactions; Idiopathic Pulmonary Fibrosis; Solid tumours	Details