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GSK-3beta

GSK-3beta

GSK-3beta Overview

Molecule Name
Glycogen synthase kinase-3 beta
Synonyms
GSK3B,Glycogen synthase kinase-3 beta
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
EC 2.7.11，EC:2.7.11.26，EC:2.7.11.1，Serine/threonine-protein kinase GSK3B，Glycogen synthase kinase-3 beta，GSK3B，Glycogen Synthase Kinase 3 Beta，GSK-3 Beta，GSK3beta Isoform，EC 2.7.11.26，EC 2.7.11.1
Background
Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD). GSK-3beta is involved in the formation of paired helical filament (PHF)-tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.

GSK-3beta Product List

Species
  • Human（1）
Tag
  • His Tag（1）
Host
  • InsectCells（1）
Conjugate
  • Unconjugated（1）
Grade
  • RUO（1）
Low Endotoxin
  • No（1）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
GSK-3beta
GSB-H5545
Human GSK-3beta / GSK-3β Protein, His Tag (active enzyme, MALS verified)
Human
InsectCells
MALSSDS-PAGE
Enzyme

$390.00

20ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
TideglusibNP-12; AMO-02; NP-031112Phase 3 ClinicalNoscira Sa
Alzheimer Disease; Amyotrophic Lateral Sclerosis; Autism Spectrum Disorder; Cardiomyopathies; Myotonic Dystrophy
Details
Ruboxistaurin Mesilate HydrateLY-333531; REC 3599; SM 030Phase 2 ClinicalEli Lilly And Company
Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic macular oedema; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Gangliosidoses, GM2; Heart Failure; Hyperpigmentation; Melanosis
Details
Elraglusib9-ING-41Phase 2 ClinicalActuate Therapeutics Inc, Northwest University, University Of Illinois At Chicago
Adenocarcinoma; Bone metastases; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Colorectal Neoplasms; Dermatofibrosarcoma; Diffuse Intrinsic Pontine Glioma; Glioma; Hemangiosarcoma; Kidney Neoplasms; Leiomyosarcoma; Leukemia-Lymphoma, Adult T-Cell; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Meningioma; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Osteosarcoma; Pancreatic Neoplasms; Primary Myelofibrosis; Rhabdomyosarcoma; Salivary Gland Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Synovial
Details
AsnuciclibCDKI-73; LS-007; QHRD-107Phase 2 ClinicalShandong University, University Of South Australia
Leukemia, Myeloid, Acute
Details
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