Gremlin

Gremlin Molekülinformation

Englischer Name	Gremlin-1	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Gremlin-1
Target-Alias	Cell proliferation-inducing gene 2 protein，Cysteine knot superfamily 1， BMP antagonist 1，DAN domain family member 2，Down-regulated in Mos-transformed cells protein，Increased in high glucose protein 2，IHG-2，CKTSF1B1，DAND2，DRM
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Gremlin Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (2)
Etikett
His Tag (1)Fc Tag (1)
Marker
Unconjugated (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
GR1-H5254	Human	HEK293	Human Gremlin / GREM1 Protein, Fc Tag				In den Warenkorb legen
GR1-H52H3	Human	HEK293	Human Gremlin / GREM1 Protein, His Tag				In den Warenkorb legen

Gesamtmenge2

Gremlin Molekülhintergrund

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Gremlin Molekülalias

GREM1,CKTSF1B1,DAND2,DRM,PIG2

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
TST-003	TST-003	Phase 2 Clinical	Suzhou Transcenta Therapeutics Co Ltd	Colorectal Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours	Details
Ginisortamab	UCB-6114	Phase 2 Clinical	Ucb Biopharma Srl	Solid tumours	Details