Frizzled-7

Frizzled-7 Molekülinformation

Englischer Name	Frizzled-7	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Frizzled-7
Target-Alias	FZD7，Frizzled-7，hFz7，Fz-7，Frizzled Class Receptor 7，Frizzled 7， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 7，FzE3，Frizzled， Drosophila， Homolog Of， 7，Frizzled (Drosophila) Homolog 7，Frizzled Homolog 7，Frizzled Homolog 7 (Drosophila)
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Frizzled-7 Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (2)
Etikett
Fc Tag (1)His Tag (1)
Marker
Unconjugated (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
FZ7-H5258	Human	HEK293	Human Frizzled-7 / FZD7 Protein, Fc Tag				In den Warenkorb legen
FZ7-H52H9	Human	HEK293	Human Frizzled-7 / FZD7 Protein, His Tag				In den Warenkorb legen

Gesamtmenge2

Frizzled-7 Molekülhintergrund

Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

Frizzled-7 Molekülalias

FZD7,Frizzled-7,FzE3,Fz-7,hFz7

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Vantictumab	OMP-18R5; anti-Fzd7	Phase 1 Clinical	Bayer AG, Oncomed Pharmaceuticals Inc	Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Osteopetrosis; Pancreatic Neoplasms; Solid tumours	Details