FOLR2

FOLR2 Molekülinformation

Englischer Name	Folate receptor beta	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias	FRbeta，FBP，Placental folate-binding protein，Folate receptor， fetal/placental，FOLR2，Folate receptor beta，Folate Receptor 2 (Fetal)，Folate-Binding Protein， Fetal/Placental，BETA-HFR，FBP/PL-1，FR-Beta，FR-P3，Folate Receptor 2，FRβ
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Englischer Name	Folate receptor beta
Target-Alias	FRbeta，FBP，Placental folate-binding protein，Folate receptor， fetal/placental，FOLR2，Folate receptor beta，Folate Receptor 2 (Fetal)，Folate-Binding Protein， Fetal/Placental，BETA-HFR，FBP/PL-1，FR-Beta，FR-P3，Folate Receptor 2，FRβ
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

FOLR2 Produktliste

Attribut
Protein (3)
Produktbibliothek
Online (3)
Spezies
Human (2)Cynomolgus (1)
Etikett
His Tag (2)His Tag & Avi Tag (1)
Marker
Unconjugated (2)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
AIDD‑Ready FO2-H5223	Human	HEK293	Human FOLR2 Protein, His Tag	In den Warenkorb legen
AIDD‑Ready FO2-H82E8	Human	HEK293	Biotinylated Human FOLR2 Protein, His,Avitag™	In den Warenkorb legen
AIDD‑Ready FO2-C52H8	Cynomolgus	HEK293	Cynomolgus FOLR2 Protein, His Tag	In den Warenkorb legen

Gesamtmenge3

Produktanfrage

FOLR2 Molekülhintergrund

Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

FOLR2 Molekülalias

FOLR2,BETA-HFR,FBP,PL-1,FR-BETA,FR-P3,FBP

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Arfolitixorin	ISO-901; 6R-MTHF	Phase 3 Clinical	Isofol Medical Ab	Colonic Neoplasms; Colorectal Neoplasms; Osteosarcoma; Rectal Neoplasms	Details
UB-TT170	UB-TT-170; UB_TT170; UB_TT-170; UB-TT170	Phase 1 Clinical	Umoja BioPharma Inc	Osteosarcoma	Details