FGF-4

Sign InRegister

English

FGF-4 Molekülinformation

Molecule Name

Fibroblast growth factor 4

Molekülalias

FGF-4, Fibroblast growth factor 4, HST, HST-1

Drug Development Progress

Anzahl der klinischen Arzneimittel1

Anzahl der inverkehr gebrachten Arzneimittel0

Höchste Forschungs- und EntwicklungsphasePhase 3 Clinical

Target-Alias

Fibroblast Growth Factor 4 Splice Isoform，Oncogene HST，K-FGF，KFGF，KS3，HBGF-4，Heparin-binding growth factor 4，HST，HSTF1，Fibroblast growth factor 4，FGF4，FGF-4，Transforming Protein KS3，Human Stomach Cancer， Transforming Factor From FGF-Related Oncogene，Heparin Secretory Transforming Protein 1，Kaposi Sarcoma Oncogene，HSTF-1，HST-1，Heparin Secretory-Transforming Protein 1

Molekülhintergrund

Fibroblast growth factor-4 (FGF4) is expressed in embryonic stages and in adult tissues, where it plays critical roles in modulating multiple cellular functions. Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. In lung adenocarcinoma (ADC) cell lines, FGF4 could alter cell morphology, promote epithelial-mesenchymal transition-associated protein expression, and enhance cell proliferation, migration/invasion and colony initiation. In B-cell lymphoma, FGF4 secretion by cancer cells induces Jag1 expression in neighbor Endothelial cell that in turn activates Notch2 in lymphoma cells.