FCRL5

FCRL5

FCRL5 Molekülinformation

Molecule Name
Fc receptor-like protein 5
Molekülalias
BXMAS1, CD307, CD307e, FCRH5, IRTA2, PRO820
Drug Development Progress
Anzahl der klinischen Arzneimittel3
Anzahl der inverkehr gebrachten Arzneimittel0
Höchste Forschungs- und EntwicklungsphasePhase 2 Clinical
Target-Alias
Fc Receptor-Like 5,CD307e Antigen,PRO820,CD307e,Fc Receptor Like 5,FcR-like protein 5,BXMAS1,Fc receptor homolog 5,FcRH5,Immune receptor translocation-associated protein 2,CD_antigen: CD307e,IRTA2,Immunoglobulin Superfamily Receptor Translocation Associated 2 (IRTA2)
Molekülhintergrund
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

FCRL5 Produktliste

Species
  • Human(5)
  • Cynomolgus(2)
  • Mouse(1)
Tag
  • His Tag(5)
  • His Tag & Avi Tag(2)
  • Fc Tag(1)
Host
  • HEK293(8)
Conjugate
  • Unconjugated(6)
  • Biotin-labeled(2)
Grade
  • RUO(8)
Low Endotoxin
  • Yes(4)
  • No(4)
MoleculeCat. No.Product NameArtHostStructurePurityActivitySize&PriceAdd to Cart
FCRL5
Cynomolgus FCRL5 Protein, His Tag, low Endotoxin (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

100ug
FCRL5
Human FCRL5 Protein, His Tag, low Endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPR

$470.00

100ug
FCRL5
HOTAvitag
FC5-H82E3
Biotinylated Human FCRL5 Protein, His,Avitag™ (MALS & SPR verified)
Human
HEK293
MALSSDS-PAGE
ELISASPR

$470.00

25ug
FCRL5
Cynomolgus FCRL5 Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE

$360.00

100ug
FCRL5
Human FCRL5 Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE

$470.00

100ug
FCRL5
Human FCRL5 (745-850) Protein, His Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE

$470.00

100ug
FCRL5
Avitag
FC5-H82Q3
Biotinylated Human FCRL5 Protein, Avitag™,His Tag (HPLC verified)
Human
HEK293
HPLCSDS-PAGE

$470.00

25ug
FCRL5
Mouse FCRL5 Protein, His Tag, low Endotoxin (MALS verified)
Mouse
HEK293
MALSSDS-PAGE

$360.00

100ug
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FAQ

What validation data should I compare when selecting an FCRL5 protein?

Relevant evidence may include purity, molecular-weight characterization, endotoxin specification, and antibody-binding activity, depending on the intended assay. Selected ACROBiosystems FCRL5 products include SDS-PAGE, SEC-MALS or HPLC, ELISA, and SPR data, but the validation package differs by catalog number. Researchers should prioritize evidence that matches the planned application rather than assume that every FCRL5 format has the same QC or bioactivity profile.

Which FCRL5 species are relevant for preclinical or cross-species studies?

ACROBiosystems provides recombinant FCRL5 proteins from human, cynomolgus monkey, and mouse. Species selection should reflect the therapeutic candidate's cross-reactivity and the biological model used during development. Construct, tag, and available validation should also be compared across species so that reagent-format differences are not mistaken for species-dependent binding differences.

Can recombinant FCRL5 proteins support anti-FCRL5 antibody characterization?

Yes. Selected ACROBiosystems FCRL5 proteins have been evaluated for anti-FCRL5/CD307e antibody binding using methods such as ELISA, with SPR data also available for specific human products. These data can inform reagent selection for antibody-binding or affinity-assay development. Results should be interpreted for the specific construct, binding partner, and assay conditions tested.

Why does the FCRL5 sequence region matter when selecting a recombinant protein?

Recombinant FCRL5 products can contain different portions of the extracellular sequence, so proteins with similar tags may not present the same target region. ACROBiosystems provides human FCRL5 proteins with different sequence boundaries, including larger extracellular constructs and selected shorter constructs. Researchers should confirm that the sequence region is appropriate for the antibody epitope or interaction being studied.

How should I choose among His-tagged, Fc-tagged, and biotinylated FCRL5 proteins?

Protein format should match the planned immobilization, capture, or detection strategy. His-tagged proteins can support compatible capture or affinity workflows, Fc-tagged formats provide an alternative immobilization configuration, and site-specifically biotinylated Avi-tag proteins can support compatible streptavidin-based assays. Product-specific construct and validation data should also be reviewed because different FCRL5 formats are not necessarily interchangeable.

How should I select an FCRL5 / CD307e protein for antibody screening or binding studies?

Start with the species and FCRL5 construct required by the experimental model, then select a tag or labeling format compatible with the planned assay. ACROBiosystems provides FCRL5 proteins in human and selected preclinical species, with product-specific antibody-binding and molecular-characterization data. Reagents should be compared by construct and demonstrated application rather than by tag alone.
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Klinische Arzneimittelinformation

Englischer NameForschungscodeForschungsphaseFirmaIndikationenKlinische Studie
anti-BCMA/FcRL5 CAR T cell therapy (Xuzhou Medical University)Phase 2 ClinicalXuzhou Medical University (Xzmu)
Multiple Myeloma
Details
Anti-FcRL5 CAR-T Cell Therapy(Xuzhou Medical University)Phase 2 ClinicalXuzhou Medical University (Xzmu)
Multiple Myeloma
Details
CevostamabRG-6160; BFCR-4350A; RO-7187797Phase 2 ClinicalGenentech Inc
Lupus Erythematosus, Systemic; Multiple Myeloma
Details
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