EphA4

EphA4 Molekülinformation

Englischer Name	Erythropoietin-producing hepatocellular receptor A4	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3	Target-Alias	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Erythropoietin-producing hepatocellular receptor A4
Target-Alias	Ephrin type-A receptor 4，EPH-like kinase 8 (EK8; hEK8)，Tyrosine-protein kinase TYRO1，Tyrosine-protein kinase receptor SEK，EPH Receptor A4，TYRO1，HEK8，Tyrosine-Protein Kinase Receptor SEK，Tyrosine-Protein Kinase TYRO1，Ephrin Type-A Receptor 4，EPH-Like Kinase 8，EC 2.7.10.1，EK8，SEK，Receptor Protein-Tyrosine Kinase HEK8，TYRO1 Protein Tyrosine Kinase，EC 2.7.10
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

EphA4 Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
EP4-H52H8	Human	HEK293	Human EphA4 Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

Produktanfrage

EphA4 Molekülhintergrund

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4 Molekülalias

EphA4,HEK8,SEK,TYRO1,EK8

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
ORT-247	ORT247; ORT-247	Phase 1 Clinical	Orthogonal Neuroscience Inc	Amyotrophic Lateral Sclerosis	Details
mEphA4-Fc	mEphA4-Fc	Phase 1 Clinical	Queensland Brain Institute	Amyotrophic Lateral Sclerosis; Nerve Degeneration; Nervous System Diseases	Details
E2025	E-2025; E2025	Phase 1 Clinical	Eisai Inc	Alzheimer Disease	Details