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Endoglin

Endoglin Overview

English Name	Endoglin	Approved Drugs	0
Drugs in Clinical Trials	2	Target Synonym	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
Highest Development Stage	Phase 2 Clinical

English Name	Endoglin
Target Synonym	CD105 Antigen，CD105，END，ENG，Osler-Rendu-Weber Syndrome 1，HHT1，ORW1，Endoglin
Approved Drugs	0
Drugs in Clinical Trials	2
Highest Development Stage	Phase 2 Clinical

Endoglin Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
ENN-H52H9	Human	HEK293	Human Endoglin / CD105 Protein, His Tag

Total: 1

Endoglin Background

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Endoglin Synonyms

Endoglin,CD105,ENG,END

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Carotuximab	DE-122; TRC-105; NSC#754227; Chimeric Antibody TRC-105; ENV-105	Phase 2 Clinical	Roswell Park Cancer Institute	Adenoma, Liver Cell; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Choriocarcinoma; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Glioblastoma; Glioma; Gliosarcoma; Hemangiosarcoma; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macular Degeneration; Metastatic breast cancer; Neoplasm Metastasis; Neoplasms; Oligodendroglioma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Solid tumours; Trophoblastic Neoplasms; Trophoblastic Tumor, Placental Site; Ureteral Neoplasms	Details
STEMVAC	EP-101	Phase 2 Clinical	Epithany	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; HR-positive breast cancer; Lung Neoplasms; Triple Negative Breast Neoplasms	Details