Select Language

EDNRA

EDNRA Overview

English Name	Endothelin receptor type A	Approved Drugs	8
Drugs in Clinical Trials	11	Target Synonym	Endothelin Receptor Type A，EDNRA，ETA-R，Endothelin-1 receptor，hET-AR，ETRA，ET-A，ETA，Endothelin-1-Specific Receptor，Endothelin Receptor Subtype A，G Protein-Coupled Receptor，ETAR，MFDA，Receptor， Endothelin A
Highest Development Stage	Approved

English Name	Endothelin receptor type A
Target Synonym	Endothelin Receptor Type A，EDNRA，ETA-R，Endothelin-1 receptor，hET-AR，ETRA，ET-A，ETA，Endothelin-1-Specific Receptor，Endothelin Receptor Subtype A，G Protein-Coupled Receptor，ETAR，MFDA，Receptor， Endothelin A
Approved Drugs	8
Drugs in Clinical Trials	11
Highest Development Stage	Approved

EDNRA Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
- (1)His Tag & Flag Tag (1)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
EDA-H51D3	Human	E. coli	Human EDNRA Full Length Protein, His,Flag Tag (Detergent)
EDA-H52P8	Human	HEK293	Human EDNRA Full Length Protein (VLP)

Total: 2

EDNRA Background

EDNRA encodes the endothelin type A receptor, a G protein-coupled receptor mediating vasoconstriction and cell proliferation upon endothelin-1 binding. Overexpression contributes to pulmonary arterial hypertension, cardiovascular disorders, and cancer progression. Selective EDNRA antagonists offer therapeutic potential for managing hypertension, fibrosis, and tumor angiogenesis.

EDNRA Synonyms

endothelin receptor type A, ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
SC-0062	SC-0062; WX-013	Phase 3 Clinical	Shijiazhuang Zhikang Hongren New Drug Development Co Ltd	Altitude Sickness; Diabetic Nephropathies; Glomerulonephritis, IGA; Kidney Diseases; Pulmonary Arterial Hypertension	Details
Zibotentan/Dapagliflozin		Phase 3 Clinical	Astrazeneca Ab, AstraZeneca global R & D (China) Co Ltd	Albuminuria; Kidney Diseases; Renal Insufficiency, Chronic	Details
Patecibart	GMA-301; GMA-301-A; GMA-301-B	Phase 2 Clinical	Gmax Biopharm Llc	Pulmonary Arterial Hypertension	Details
Zibotentan	ZD-4054; AZD-4054	Phase 2 Clinical	Astrazeneca Plc	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Hepatic Insufficiency; Hypertension, Portal; Intermittent Claudication; Liver Cirrhosis; Lung Neoplasms; Metastatic breast cancer; Microvascular Angina; Neoplasm Metastasis; Ovarian Neoplasms; Peripheral Arterial Disease; Prostatic Neoplasms; Renal Insufficiency; Renal Insufficiency, Chronic; Scleroderma, Limited; Scleroderma, Systemic; Solid tumours	Details
SAL-0120	SAL-0120; SAL0120	Phase 2 Clinical	Shenzhen Salubris Pharmaceuticals Co Ltd	Essential Hypertension; Glomerulonephritis, IGA; Hypertension; Renal Insufficiency, Chronic	Details
HS-10390	HS-10390; HS10390	Phase 2 Clinical	Changzhou Hengbang Pharmaceutical Co Ltd, Shanghai Hansoh Biomedical Co Ltd	Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Renal Insufficiency, Chronic	Details
BQ-123	CGS-26343; BQ-123; PMZ-2123	Phase 1 Clinical	Midwestern University	Cardiovascular Diseases; Coronary Artery Disease; Diabetic Ketoacidosis; Heart Failure; Hypertension; Hypertension, Pulmonary; Hypoxia, Brain; Metabolic Syndrome; Multiple System Atrophy; Pain; Proteinuria; Pure Autonomic Failure; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction	Details
GMA-131	GMA-131	Phase 1 Clinical	Gmax Biopharm Llc, Gmaxx Biologics Ltd	Diabetic Nephropathies	Details
AK-1960	AK1960; AK-1960	Phase 1 Clinical		Renal Insufficiency, Chronic	Details
GLX-002	GLX-002; GLX002	Phase 1 Clinical	Yabao Pharmaceutical Co Ltd Beijing	Pulmonary Arterial Hypertension	Details
Bosentan Orally Disintegrating Tablets(Beijing Sunho Pharma)		Phase 1 Clinical	Beijing Sunho Pharmaceutical Co Ltd	Pulmonary Arterial Hypertension	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Clazosentan Sodium	Ro-61-1790; ACT-108475; AXV-034; VML-588; AXV-034343	Approved	F. Hoffmann-La Roche Ltd	Pivlaz	Japan	Subarachnoid Hemorrhage; Brain Ischemia; Vasospasm, Intracranial; Cerebral Infarction	Idorsia Pharmaceuticals Ltd	2022-01-20	Aneurysm; Brain Ischemia; Cerebral Infarction; Subarachnoid Hemorrhage; Vasospasm, Intracranial	Details
Macitentan/Tadalafil		Approved	Actelion Pharmaceuticals Ltd	OPSYNVI, Yuvanci	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Us Inc	2024-03-22	Phenylketonurias; Pulmonary Arterial Hypertension	Details
Ambrisentan	LU-208075; BSF-208075; GSK-132576A	Approved	Abbott Laboratories	Letairis, Volibris, 凡瑞克	United States	Pulmonary Arterial Hypertension	Gilead Sciences Inc	2007-06-15	Acute Kidney Injury; Anemia, Sickle Cell; Ascites; Coronavirus Disease 2019 (COVID-19); Hepatorenal Syndrome; Hypertension; Hypertension, Portal; Hypertension, Pulmonary; Hypoxia; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Pulmonary Arterial Hypertension; Sarcoidosis; Scleroderma, Systemic; Thromboembolism; Vascular Diseases	Details
Sparsentan	PS-433540; BMS-346567; RE-021	Approved	Bristol-Myers Squibb Company	Filspari	United States	Glomerulonephritis, IGA	Travere Therapeutics Inc	2023-02-17	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Autoimmune Diseases; Cardiovascular Diseases; Glomerulonephritis; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Hypertension; Immune System Diseases; Kidney Diseases; Nephritis, Hereditary; Nephrosis, Lipoid; Proteinuria; Purpura, Schoenlein-Henoch	Details
Bosentan Hydrate	ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039	Approved	F. Hoffmann-La Roche Ltd	Stayveer, 全可利, Tracleer	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Ltd	2001-11-20	Anemia, Sickle Cell; Chronic thromboembolic pulmonary hypertension; Coronary Vasospasm; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fibrosis; Giant Cell Arteritis; Glaucoma; Heart Defects, Congenital; Heart Septal Defects, Atrial; Hepatopulmonary Syndrome; Hypertension; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Lung Diseases, Interstitial; Persistent Fetal Circulation Syndrome; Pulmonary Arterial Hypertension; Pulmonary Fibrosis; Sarcoidosis; Scleroderma, Systemic; Sleep Apnea Syndromes; Takayasu Arteritis; Ulcer; Vasculitis	Details
Macitentan	ACT-064992; Actelion-1; JNJ-67896062	Approved	Actelion Pharmaceuticals Ltd	Zependo, Opsumit, 傲朴舒	United States	Pulmonary Arterial Hypertension	Actelion Pharmaceuticals Us Inc	2013-10-18	Anemia, Sickle Cell; Angina Pectoris; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Eisenmenger Complex; Glioblastoma; Heart Defects, Congenital; Heart Failure; Heart Failure, Diastolic; Hypertension, Pulmonary; Idiopathic Pulmonary Fibrosis; Pulmonary Arterial Hypertension; Pulmonary Embolism; Scleroderma, Systemic; Scleroderma-associated interstitial lung diseases; Thromboembolism; Ulcer	Details
Aprocitentan	ACT-132577; AC-080; JNJ-2820	Approved	Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd	TRYVIO, JERAYGO	United States	Hypertension	Idorsia Pharmaceuticals Ltd	2024-03-19	Essential Hypertension; Hepatic Insufficiency; Hypertension; Renal Insufficiency, Chronic	Details
Atrasentan hydrochloride	ABT-147627; (+)-A-127722; Abbott-147627; A-147627; ABT-627; A-1476271; CHK-01; EXV 811	Approved	Abbvie Inc	Vanrafia, 诺锐达, Xinlay	United States	Glomerulonephritis, IGA; Proteinuria	Novartis Pharmaceutical Corp, Novartis Pharma Ag	2025-04-02	Abdominal Neoplasms; Adenocarcinoma; CNS Embryonal Tumor; Diabetes Mellitus; Diabetic Nephropathies; Fallopian Tube Neoplasms; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Kidney Diseases; Kidney Neoplasms; Neoplasm Metastasis; Nephritis, Hereditary; Ovarian Neoplasms; Prostatic Neoplasms; Proteinuria; Renal Insufficiency, Chronic; Vascular Diseases	Details