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DNase I

DNase I Overview

English Name	Deoxyribonuclease 1	Approved Drugs	1
Drugs in Clinical Trials	1	Target Synonym	EC:3.1.21.1，Deoxyribonuclease I，Dornase alfa，DNase I， Lysosomal，DNase I，DNL1，DNASE1，Deoxyribonuclease 1，DRNI，Human Urine Deoxyribonuclease I，Deoxyribonuclease-1，EC 3.1.21.1
Highest Development Stage	Approved

English Name	Deoxyribonuclease 1
Target Synonym	EC:3.1.21.1，Deoxyribonuclease I，Dornase alfa，DNase I， Lysosomal，DNase I，DNL1，DNASE1，Deoxyribonuclease 1，DRNI，Human Urine Deoxyribonuclease I，Deoxyribonuclease-1，EC 3.1.21.1
Approved Drugs	1
Drugs in Clinical Trials	1
Highest Development Stage	Approved

DNase I Product List

Product Category
Kits (1)
Product Status
Launched (1)
Species
Bovine (1)
Tag
- (1)
Conjugate
- (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
HOT ASE-A002	Bovine	-	resDetect™ DNase Activity Assay Kit (Fluorescence)

Total: 1

DNase I Background

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).

DNase I Synonyms

DNase I,Deoxyribonuclease-1,Deoxyribonuclease I

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
repurposed deoxyribonuclease I (Human Microbiology Institute)		Clinical		Alzheimer Disease	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Chorionic Gonadotropin	LDI-200	Approved	Angiogene Pharmaceuticals						Prostatic Neoplasms; Leukemia, Myeloid, Acute; Infertility, Female; Hypogonadism; Cryptorchidism	Details