Dkk-3

Dkk-3 Molekülinformation

Englischer Name	Dickkopf-related protein 3	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Dickkopf-related protein 3
Target-Alias	Dickkopf 3 Homolog (Xenopus Laevis)，UNQ258/PRO295，Dickkopf-3，Dickkopf-related protein 3，hDkk-3，REIC，DKK3，Dickkopf WNT Signaling Pathway Inhibitor 3，Regulated In Glioma，Dkk-3，Dickkopf (Xenopus Laevis) Homolog 3，Dickkopf 3 Homolog，Dickkopf Homolog 3，RIG-Like 5-6，RIG-Like 7-1，RIG
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Dkk-3 Produktliste

Attribut
Protein (2)
Produktbibliothek
Online (2)
Spezies
Human (1)Mouse (1)
Etikett
His Tag (2)
Marker
Unconjugated (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
DK3-H5220	Human	HEK293	Human Dkk-3 (R335G) Protein, His Tag				In den Warenkorb legen
DK3-M5226	Mouse	HEK293	Mouse Dkk-3 Protein, His Tag				In den Warenkorb legen

Gesamtmenge2

Dkk-3 Molekülhintergrund

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.