CXCR3
CXCR3 Molekülinformation
| Englischer Name | C-X-C motif chemokine receptor 3 | Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 | Target-Alias | CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3 |
| Höchste Forschungs- und Entwicklungsphase | Phase 1 Clinical | ||
| Englischer Name | C-X-C motif chemokine receptor 3 |
| Target-Alias | CKR-L2，G protein-coupled receptor 9，IP-10 receptor，CXCR-3，CXC-R3，CXCR3，C-X-C Motif Chemokine Receptor 3，Interferon-Inducible Protein 10 Receptor，GPR9，C-X-C Chemokine Receptor Type 3，Chemokine Receptor 3，CD183 Antigen，CMKAR3，Chemokine (C-X-C Motif) Receptor 3，Mig Receptor，IP10-R，CD182，CD183，Mig-R，MigR，Receptors， CXCR3 |
| Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 |
| Höchste Forschungs- und Entwicklungsphase | Phase 1 Clinical |
CXCR3 Produktliste
- Attribut
Protein (4)Cell (2)
- Produktbibliothek
Online (6)
- Spezies
Human (5)Mouse (1)
- Etikett
- (5)His Tag & Flag Tag (1)
- Marker
Unconjugated (3)- (2)Biotin-labeled (1)
| Produktnummer | Spezies | Expressionssystem | Produktbeschreibung | Proteinstruktur | Reinheit | Eigenschaften | Vorbestellen/Bestellen |
|---|---|---|---|---|---|---|---|
 Human | HEK293 | Human CXCR3 Protein, Flag,His Tag (Detergent) |  |  |  In den Warenkorb legen | ||
| Human | CHO | CHO/Human CXCR3 Stable Cell Line |  | In den Warenkorb legen | |||
| Human | HEK293 | HEK293/Human CXCR3 Stable Cell Line | | In den Warenkorb legen | |||
| Human | HEK293 | Human CXCR3 Full Length Protein (VLP) | | In den Warenkorb legen | |||
| Human | HEK293 | Biotinylated Human CXCR3 Full Length Protein (VLP) | | In den Warenkorb legen | |||
 Mouse | HEK293 | Mouse CXCR3 Full Length Protein (VLP) | | In den Warenkorb legen |
Gesamtmenge6
- 1
CXCR3 Molekülhintergrund
Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.
CXCR3 Molekülalias
CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR
Klinische Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Indikationen | Klinische Studie |
|---|---|---|---|---|---|
| OCU-110 | OCU-10-C-110; OGX-110; OCU-110 | Phase 1 Clinical | Ocugenix Corp | Macular Degeneration | Details |
| ACT-777991 | ACT-777991 | Phase 1 Clinical | Idorsia Pharmaceuticals Ltd | Diabetes Mellitus, Type 1; Inflammation | Details |
- Molekülinformation
- Produktliste
- Klinische Arzneimittelinformation