CTGF

CTGF Molekülinformation

Englischer Name	Connective tissue growth factor	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	5	Target-Alias	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Connective tissue growth factor
Target-Alias	Cellular communication network factor 2，IBP-8，Hypertrophic chondrocyte-specific protein 24，IGF-binding protein 8，IGFBP-8，Connective tissue growth factor，IGFBP8，CCN2，Insulin-like growth factor-binding protein 8，HCS24，CCN family member 2，CTGF，NOV2
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	5
Höchste Forschungs- und Entwicklungsphase	Approved

CTGF Produktliste

Attribut
Protein (5)
Produktbibliothek
Online (5)
Spezies
Human (3)Mouse (1)Rhesus macaque (1)
Etikett
His Tag & Avi Tag (1)His Tag (3)Fc Tag (1)
Marker
Biotin-labeled (1)Unconjugated (4)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CTF-H52H5	Human	HEK293	Human CTGF / CCN2 Protein, His Tag	In den Warenkorb legen
HOT CTF-H82E6	Human	HEK293	Biotinylated Human CTGF / CCN2 Protein, His,Avitag™ (recommended for biopanning)	In den Warenkorb legen
HOT GTF-H5253	Human	HEK293	Human CTGF / CCN2 Protein, Fc Tag	In den Warenkorb legen
HOT GTF-R52H4	Rhesus macaque	HEK293	Rhesus macaque CTGF / CCN2 Protein, His Tag	In den Warenkorb legen
CTF-M52Hc	Mouse	HEK293	Mouse CTGF / CCN2 Protein, His Tag	In den Warenkorb legen

Gesamtmenge5

CTGF Molekülhintergrund

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

CTGF Molekülalias

CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Pamrevlumab	FG-3019	Phase 3 Clinical	Fibrogen Inc	Coronavirus Disease 2019 (COVID-19); Diabetes Mellitus; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glomerulosclerosis, Focal Segmental; Idiopathic Pulmonary Fibrosis; Liver Cirrhosis; Muscular Dystrophy, Duchenne; Pancreatic Neoplasms	Details
OLX-10010	cp-asiCTGF; OLX-101A; OLX-10010; BMT-101; OLX-101	Phase 2 Clinical	Olix Pharmaceuticals Inc	Cicatrix, Hypertrophic; Macular Degeneration; Pulmonary Fibrosis; Wet Macular Degeneration	Details
SHR-1906	SHR-1906	Phase 2 Clinical	Guangdong Hengrui Pharmaceutical Co Ltd	Idiopathic Pulmonary Fibrosis	Details
PRS-220	PRS-220	Phase 1 Clinical	Pieris Pharmaceuticals	Idiopathic Pulmonary Fibrosis	Details
LEM-S401	LEM-S401; LEMS401	Phase 1 Clinical	Lemonex Inc	Cicatrix	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Penicillamine		Approved	Valeant	Distamine, Pemine, Trisorcin, Cuprimine, Cupramine, Trolovol	United States	Arthritis, Rheumatoid; Hepatolenticular Degeneration; Cystinuria	Bausch Health Companies Inc	1970-12-04	Arthritis, Rheumatoid; Cystinuria; Heavy Metal Poisoning; Hepatolenticular Degeneration; Lead Poisoning	Details