CR2

Epstein-Barr virus (EBV), also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV binds to the cell surface receptor 2 (CD21/CR2) on human B cells using its major envelope glycoprotein 350 (gp350) and, as such, the EBV gp350 Envelope Protein, also designated the EBV envelope glycoprotein complex 250/350, is crucial in mediating the initial stages of EBV infection. The EBV gp350 Envelope Protein is expressed on virion envelope as well as EBV producer cells.