Complement Factor D

Complement Factor D Molekülinformation

Englischer Name	Complement factor D	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	5	Target-Alias	EC 3.4.21，EC 3.4.21');，C3 Convertase Activator，ADIPSIN，D Component Of Complement (Adipsin)，PFD，Complement Factor D Preproprotein，Complement Factor D (Adipsin)，EC 3.4.21.46，ADN，CFD，Properdin factor D，DF，Complement factor D，EC:3.4.21.46
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Complement factor D
Target-Alias	EC 3.4.21，EC 3.4.21');，C3 Convertase Activator，ADIPSIN，D Component Of Complement (Adipsin)，PFD，Complement Factor D Preproprotein，Complement Factor D (Adipsin)，EC 3.4.21.46，ADN，CFD，Properdin factor D，DF，Complement factor D，EC:3.4.21.46
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	5
Höchste Forschungs- und Entwicklungsphase	Approved

Complement Factor D Produktliste

Attribut
Protein (3)
Produktbibliothek
Online (3)
Spezies
Human (2)Cynomolgus / Rhesus macaque (1)
Etikett
His Tag (2)Fc Tag (1)
Marker
Unconjugated (3)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CFD-H5256	Human	HEK293	Human Complement Factor D / CFD Protein, Fc Tag	In den Warenkorb legen
HOT CFD-H52H8	Human	HEK293	Human Complement Factor D / CFD Protein, His Tag (active enzyme)	In den Warenkorb legen
CFD-R52H3	Cynomolgus / Rhesus macaque	HEK293	Rhesus macaque / Cynomolgus Complement Factor D / CFD Protein, His Tag (active enzyme)	In den Warenkorb legen

Gesamtmenge3

Complement Factor D Molekülhintergrund

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor D Molekülalias

CFD,Adipsin,PFD,DF,Complement factor D

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Vemircopan	ACH-0145228; ACH-5228; ALXN-2050	Phase 1 Clinical	Achillion Pharmaceuticals Inc	Glomerulonephritis, IGA; Hemoglobinuria, Paroxysmal; Hepatic Insufficiency; Lupus Nephritis; Myasthenia Gravis; Renal Insufficiency	Details
ACH-5548	ACH-5548; ACH-0145548	Phase 1 Clinical	Achillion Pharmaceuticals Inc	Autoimmune Diseases	Details
BCX-9930	BCX-9930	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	C3 glomerulopathy; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Hemoglobinuria, Paroxysmal	Details
BCX-10013	BCX-10013	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	Hemoglobinuria, Paroxysmal	Details
Zoracopan	ALXN-2080	Phase 1 Clinical	Alexion Pharmaceuticals Inc		Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Danicopan	ACH-4471; ACH-0144471; ACH-CFDIS; ALXN-2040	Approved	Achillion Pharmaceuticals Inc	VOYDEYA, Voydeya	Japan	Hemoglobinuria, Paroxysmal	Alexion Pharmaceuticals Inc	2024-01-18	C3 glomerulopathy; Coronavirus Disease 2019 (COVID-19); Geographic Atrophy; Glomerulonephritis, Membranoproliferative; Hemoglobinuria, Paroxysmal; Hemolysis; Hepatic Insufficiency	Details