COMP

COMP Molekülinformation

Englischer Name	Sodium channel protein type VIII alpha subunit	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	4	Target-Alias	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Sodium channel protein type VIII alpha subunit
Target-Alias	Sodium Channel， Voltage Gated， Type VIII Alpha Subunit，Voltage-Gated Sodium Channel Type VIII Alpha Protein，HNa6/Scn8a Voltage-Gated Sodium Channel，CERIII，EIEE13，Nav1.6，BFIS5，NaCh6，CIAT，PN4，NAV1.6 Voltage-Gated Sodium Channel，MYOCL2，Sodium channel protein type 8 subunit alpha，Sodium channel protein type VIII subunit alpha，MED，SCN8A，Sodium Voltage-Gated Channel Alpha Subunit 8，Sodium Channel， Voltage Gated， Type VIII， Alpha Subunit，Voltage-Gated Sodium Channel Subunit Alpha Nav1.6，Sodium Channel， Voltage Gated， Type VIII， Alpha Polypeptide
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	4
Höchste Forschungs- und Entwicklungsphase	Approved

COMP Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
COP-H5220	Human	HEK293	Human COMP / TSP5 Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

COMP Molekülhintergrund

Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.

COMP Molekülalias

COMP,TSP5,EDM1,EPD1,MED,PSACH,THBS5

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
PRAX-562	PRAX-562	Phase 3 Clinical	Praxis Precision Medicines	Brain Diseases; Epilepsy	Details
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Epilepsies, Partial; Brain Diseases; Epilepsy	Details
PRAX-330	GS-458967; GS-967; PRAX-330	Phase 1 Clinical	Praxis Precision Medicines Inc	Epilepsy	Details
NBI-355	NBI-355	Phase 1 Clinical	Neurocrine Biosciences Inc	Epilepsy	Details