Clusterin

Clusterin Molekülinformation

Englischer Name	Clusterin	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Clusterin
Target-Alias	Epididymis Secretory Sperm Binding Protein，CLI，Apolipoprotein J，ApoJbeta，Complement cytolysis inhibitor a chain，Testosterone-repressed prostate message 2，Complement cytolysis inhibitor b chain，ApoJalpha，AAG4，Complement cytolysis inhibitor，NA1/NA2，APOJ，CLU，Clusterin，Complement-Associated Protein SP-40，40，Complement Lysis Inhibitor，Sulfated Glycoprotein 2，Ku70-Binding Protein 1，TRPM-2，KUB1，Clusterin (Complement Lysis Inhibitor， SP-40，40， Sulfated Glycoprotein 2， Testosterone-Repressed Prostate Message 2， Apolipoprotein J)，Aging-Associated Gene 4 Protein，Aging-Associated Protein 4，APO-J，SGP-2，SP-40，CLU1，CLU2，SGP2，TRPM2
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Clusterin Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
CLU-H5227	Human	HEK293	Human Clusterin / CLUS Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

Clusterin Molekülhintergrund

Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa Nglycosylated disulfidelinked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Clusterin Molekülalias

CLU,Clusterin,AAG4,APOJ,CLI,KUB1,SGP-2,SP-40,TRPM2

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Sotevtamab	AB-sCLU mAB; 16B5; AB-16B5	Phase 2 Clinical	National Research Council Biotechnology Research Institute	Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Neoplasm Metastasis; Solid tumours	Details