CLEC7A

CLEC7A Molekülinformation

Englischer Name	C-type lectin domain family 7 member A	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A
Höchste Forschungs- und Entwicklungsphase	Clinical

Englischer Name	C-type lectin domain family 7 member A
Target-Alias	C-type lectin superfamily member 12，Beta-glucan receptor，CD369，Dendritic cell-associated C-type lectin 1，DC-associated C-type lectin 1，BGR，CANDF4，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 12，SCARE2，HDectin-1，CD369 Antigen，Dendritic Cell-Associated C-Type Lectin-1，DECTIN1，C-Type Lectin Domain Family 7， Member A，Lectin-Like Receptor 1，CLECSF12，Dectin-1，C-Type Lectin Domain Containing 7A
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Clinical

CLEC7A Produktliste

Attribut
Protein (8)
Produktbibliothek
Online (8)
Spezies
Human (3)Cynomolgus (2)Mouse (3)
Etikett
His Tag (4)His Tag & Avi Tag (2)Fc Tag (2)
Marker
Unconjugated (6)Biotin-labeled (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CL7-H5243	Human	HEK293	Human CLEC7A Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
CL7-H5248	Human	HEK293	Human CLEC7A Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
CLA-H5264	Human	HEK293	Human CLEC7A Protein, Fc Tag (MALS verified)	In den Warenkorb legen
CL7-M5243	Mouse	HEK293	Mouse CLEC7A Protein, His Tag (HPLC verified)	In den Warenkorb legen
CL7-M82Q3	Mouse	HEK293	Biotinylated Mouse CLEC7A Protein, Avitag™,His Tag (MALS verified)	In den Warenkorb legen
CLA-M5263	Mouse	HEK293	Mouse CLEC7A Protein, Fc Tag (MALS verified)	In den Warenkorb legen
CL7-C5243	Cynomolgus	HEK293	Cynomolgus CLEC7A Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
CLA-C82Q3	Cynomolgus	HEK293	Biotinylated Cynomolgus CLEC7A Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen

Gesamtmenge8

CLEC7A Molekülhintergrund

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).