Claudin-18.2

Claudin-18.2 Overview

English NameClaudin-18 splice variant 2Approved Drugs1
Drugs in Clinical Trials85Target SynonymUNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2,CLDN18.2
Highest Development StageApproved
English NameClaudin-18 splice variant 2
Target SynonymUNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2,CLDN18.2
Approved Drugs1
Drugs in Clinical Trials85
Highest Development StageApproved

Claudin-18.2 Product List

  • Product Category

    Protein (11)Cell (1)Antibody (1)

  • Product Status

    Launched (13)

  • Species

    Human / Cynomolgus (6)Human (4)Mouse (3)

  • Tag

    His Tag & Strep Tag (3)- (8)GFP Tag (1)His Tag & Flag Tag (1)

  • Conjugate

    Unconjugated (7)- (1)GFP Fusion (1)Biotin-labeled (3)PE Labeled (1)

Claudin-18.2 Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Claudin-18.2 Synonyms

Claudin-18.2,CLDN18,Claudin-18

Antibody Project Trading Platform

Project NameProject StageMolecule TypeMolecule SourceDisease AreaIndication
CLDN18.2 CAR-T - 01PhaseICARNanobodySolid TumorAdvanced refractory gastrointestinal tumors
CLDN18.2 VHH - 01LeadMonoclonalNanobodySolid TumorGastric Cancer,Pancreatic cancer

Project Cooperation

Project NameDrug TypeTherapeutic AreaIndicationStageRights Area
Claudin18.2×CD8+ T bsAbBispecific antibodyOncology/CancerGastric cancer,Pancreatic cancer,OophoromaINDGlobal
CLDN 18.2 CAR-TCell therapyOncology/CancerGastric Cancer,Pancreatic CancerINDGlobal
Claudin18.2 mAbMonospecific antibodyOncology/CancerGastric cancerPhase IGlobal

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
OsemitamabMSB-018; TST-001Phase 3 ClinicalHJB (Hangzhou) Co Ltd, Suzhou Transcenta Therapeutics Co LtdBiliary Tract Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Gastroesophageal Junction Neoplasms; Lung Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
XNW-27011XNW-27011Phase 3 ClinicalEvopoint Biosciences Co LtdAdenocarcinoma; Biliary Tract Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastroesophageal Junction Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms
Details
IMC-002 (Suzhou Immunofoco)IMC-002Phase 3 ClinicalSuzhou Immunofoco Biotechnology Co LtdDigestive System Neoplasms; Gastroesophageal Junction Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Details
Arcotatug tavatecanIBI-343; IBI343Phase 3 ClinicalInnovent Biologics(Suzhou) Co LtdAdenocarcinoma; Carcinoma, Pancreatic Ductal; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
LB-4330LB-4330; Bis-2Phase 3 ClinicalL&L Biopharma Co LtdSolid tumours; Uterine Cervical Neoplasms
Details
JS-107JS-107; JS107Phase 3 ClinicalShanghai Junshi Biosciences Co LtdAdenocarcinoma; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
Tecotabart vedotinTPX-4589; BMS-986476; LM-302Phase 3 ClinicalLaNova Medicines LtdAdenocarcinoma; Digestive System Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
QLS-31905QLS-31905Phase 3 ClinicalQilu Pharmaceutical Co LtdBile Duct Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
SYSA-1801SYSA1801; CPO-102; EO-3021; SYSA-1801Phase 3 ClinicalCSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co LtdDigestive System Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
Garetatug RezetecanSHR-A-1904; SHR-A1904Phase 3 ClinicalShanghai Hengrui Pharmaceutical Co LtdBile Duct Neoplasms; Biliary Tract Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Lymphangioma, Cystic; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
FG-M-108FG-M-108; M108; M-108Phase 3 ClinicalFutureGen Biopharm (Beijing) Co LtdEsophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
Sonesitatug VedotinCMG-901; CMG901; AZD-0901; AZD0901Phase 3 ClinicalKeymed Biosciences Co LtdBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
ASKB-589ASKB-589Phase 3 ClinicalAskGene Pharma Inc, Jiangsu Aosaikang Pharmaceutical Co LtdAdenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
KD-182KD-182Phase 2 ClinicalNanjing Kaidi Medical Technology Co LtdCarcinoma, Pancreatic Ductal; Stomach Neoplasms
Details
CLDN18.2-TAC T cells TherapyCLDN-18.2-TAC T cells; CLDN18.2-TAC T cellsPhase 2 ClinicalTriumvira Immunologics IncSolid tumours; Stomach Neoplasms
Details
HBM-7022HBM-7022; AZD-5863Phase 2 ClinicalHarbour BiomedCarcinoma, Pancreatic Ductal; Esophageal adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Details
EB-DNK102EB-DNK102Phase 2 ClinicalBeijing BiotechCarcinoma, Pancreatic Ductal
Details
Claudin18.2 targeting CAR-T cell therapy (Essen Biotech)Phase 2 ClinicalEssen BiotechPancreatic Neoplasms
Details
AZD-4360AZD4360; AZD-4360Phase 2 ClinicalAstrazeneca AbBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Gastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
Details
BDC-4182BD-4182; BDC-4182Phase 2 ClinicalBolt Biotherapeutics IncAdenocarcinoma; Esophageal Neoplasms; Neoplasms; Stomach Neoplasms
Details
LCB-02ALCB-02APhase 2 ClinicalLegochem Biosciences IncHematologic Neoplasms; Solid tumours
Details
PM-1032PM1032; PM-1032Phase 2 ClinicalShanghai Genechem Co LtdNeoplasms; Pancreatic Neoplasms
Details
SpevatamigPT-886; PT886Phase 2 ClinicalPhanes Therapeutics IncBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
SKB-315SKB-315; SKB315; MK1200; MK-1200Phase 2 ClinicalSichuan Kelun-Biotech Biopharmaceutical Co LtdEsophageal Neoplasms; Solid tumours; Stomach Neoplasms
Details
ATG-022ATG-022; ATN-022Phase 2 ClinicalAntengene Corporation Co LtdGastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
Details
SOT-102SOT-102; SOT102; SO-N102Phase 2 ClinicalSotio Biotech AGPancreatic Neoplasms; Stomach Neoplasms
Details
GivastomigTJ-CD4B; ABL-111; TJ-CLDN4B; TJ-033721; TJ-CD4B/ABL111Phase 2 ClinicalI-Mab Biopharma Co LtdBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Neoplasm Metastasis; Neoplasms; Solid tumours; Stomach Neoplasms
Details
Q-1802Q-1802Phase 2 ClinicalQure Biotechnology (Shanghai) Co LtdEsophageal Neoplasms; Gastrointestinal Neoplasms; Solid tumours
Details
Recombinant humanized monoclonal antibody MIL93(Mabworks)MIL-93Phase 2 ClinicalBeijing Mabworks Biotech Co LtdGastroesophageal Junction Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
RC-118RC-118; YH005 ADCPhase 2 ClinicalGastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
Details
Recombinant humanized anti-Claudin 18.2 monoclonal antibody (CARsgen)AB-011Phase 1 ClinicalCarsgen Biomedicine (Shanghai) Co Ltd, Kaixing Life Technology (Shanghai) Co LtdEsophageal Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
KD-496KD-496(4th); KD-496Phase 1 ClinicalNanjing Kaidi Medical Technology Co LtdNeoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
Claudin18.2 Targeted CAR-T Cells therapy (Frontiergate Biopharm)Phase 1 ClinicalFrontiergate Biopharm (Hainan) Co LtdPancreatic Neoplasms
Details
Claudin18.2 Targeted Activated Dendritic Cells therapy (Frontiergate Biopharm)Phase 1 ClinicalFrontiergate Biopharm (Hainan) Co LtdPancreatic Neoplasms
Details
CBG-131CBG-131; CBG131Phase 1 ClinicalCarbiogene Therapeutics Co LtdPancreatic Neoplasms; Stomach Neoplasms
Details
Claudin18.2 CAR-T cell therapy (Ucello Therapeutics)Phase 1 ClinicalUcello Therapeutics Co LtdSolid tumours
Details
GresonitamabAMG-910Phase 1 ClinicalAmgen IncAdenocarcinoma; Esophageal Neoplasms; Stomach Neoplasms
Details
Claudin18.2-targeted CAR-DCs therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine)Phase 1 ClinicalSecond Affiliated Hospital School Of Zhejiang University School Of MedicineColorectal Neoplasms
Details
Claudin18.2-targeted CAR-T Cells therapy (Second Affiliated Hospital School Of Zhejiang University School Of Medicine)Phase 1 ClinicalSecond Affiliated Hospital School Of Zhejiang University School Of MedicineColorectal Neoplasms
Details
CT-225XKDCT225; XKDCT-225; CT225Phase 1 ClinicalShenzhen Celconta Life Science Co LtdSolid tumours
Details
SIBP-A18SIBPA18; SIBP-A18Phase 1 ClinicalShanghai Institute of Biological Products Co LtdSolid tumours
Details
[68Ga]Ga-NODAGA-SNA01468Ga-SNA014; [68Ga]Ga-NODAGA-SNA014; SNA-014Phase 1 ClinicalSmartnuclide BiopharmaAdenocarcinoma; Pancreatic Neoplasms
Details
HD-004HD004; HD-004Phase 1 ClinicalHuadao (Shanghai) Biopharma Co LtdSolid tumours
Details
SPX-102SPX-102Phase 1 ClinicalSparx Therapeutics IncNeoplasms
Details
Cord Blood-Derived CAR-NK Cells therapy (Rongu Biotechnology)CB CAR-NK182; RG-CLDN18.2Phase 1 ClinicalHangzhou Rongu Biotechnology Co LtdPancreatic Neoplasms; Stomach Neoplasms
Details
LNF-2007LNF-2007; LNF2007Phase 1 ClinicalShandong New Time Pharmaceutical Co LtdSolid tumours
Details
BL-M05D1BL-M05D1; BLM05D1Phase 1 ClinicalSichuan Baili Pharmaceutical Co Ltd, SystImmuneBiliary Tract Neoplasms; Carcinoma, Pancreatic Ductal; Esophageal adenocarcinoma; Solid tumours; Stomach Neoplasms
Details
AHT-102AHT102; AHT-102Phase 1 ClinicalGuangxi Lugang Biomedical Technology Co LtdSolid tumours
Details
AZD-6422AZD6422; AZD-6422Phase 1 ClinicalAstrazeneca PlcGastrointestinal Neoplasms
Details
GC-506GC506; GC-506Phase 1 ClinicalGracell Biotechnologies (Shanghai) Co LtdGastroesophageal Junction Neoplasms; Solid tumours; Stomach Neoplasms
Details
68Ga-PMD22(Peking Union Medical College Hospital)Phase 1 ClinicalPeking Union Medical College HospitalGastrointestinal Neoplasms
Details
AK-132AK132; AK-132Phase 1 ClinicalNeoplasms; Solid tumours
Details
AHT-101AHT-101; AHT101Phase 1 ClinicalGuangxi Lugang Biomedical Technology Co LtdSolid tumours
Details
TQB-2103TQB2103; TQB-2103Phase 1 ClinicalNanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical GroupNeoplasms
Details
BIO-008BIO-008Phase 1 ClinicalShijiazhuang Yiling Pharmaceutical Co LtdSolid tumours
Details
BA-1301BA-1301; BA1301Phase 1 ClinicalShandong Boan Biotechnology Co LtdEsophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
RB-0011RB0011; RB-0011Phase 1 ClinicalRuiyang (Suzhou) Biological Technology Co LtdSolid tumours
Details
LB-1904LB-1904Phase 1 ClinicalStomach Neoplasms
Details
Ori-C-613Ori-C-613; OriC-613; Ori-C613Phase 1 ClinicalOriCell Therapeutics Co LtdSolid tumours
Details
CT-048CT-048; KJ-C1807; KJ-C-1807Phase 1 ClinicalCarsgen Biomedicine (Shanghai) Co LtdGastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Details
ASP-2138ASP-2138Phase 1 ClinicalAstellas Pharma Global Development Inc, Xencor IncCarcinoma, Pancreatic Ductal; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Details
HEC-016HEC-016Phase 1 ClinicalPeople Hospital Of Luohu,ShenzhenEsophageal Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Details
PM-3023PM-3023Phase 1 ClinicalSolid tumours
Details
RD-07RD-07Phase 1 ClinicalPeking UniversitySolid tumours
Details
IBI-345IBI-345Phase 1 ClinicalSolid tumours
Details
TORL-2-307-MABTORL-2-307-MABPhase 1 ClinicalTorl Biotherapeutics LLCGastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
TORL-2-307-ADCTORL-2-307-ADCPhase 1 ClinicalTorl Biotherapeutics LLCGastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
BC-008BC-008Phase 1 ClinicalDragonboat BiopharmaceuticalNeoplasms; Solid tumours
Details
BC-007 (Dragonboat Biopharmaceutical)BC-007Phase 1 ClinicalDragonboat BiopharmaceuticalNeoplasms; Solid tumours
Details
DR-30303DR-30303Phase 1 ClinicalZhejiang Doer Biologics CorpSolid tumours
Details
SG-1906SG-1906; SG1906Phase 1 ClinicalHangzhou Shangjian Biotechnology Co LtdNeoplasms; Solid tumours
Details
BA-1105BA1105; BA-1105Phase 1 ClinicalShandong Boan Biotechnology Co LtdEsophageal Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
CLDN 18.2 CAR-T cell therapy (Shanghai Longyao)LY-011Phase 1 ClinicalShanghai Longyao Biological Technology Co LtdPancreatic Neoplasms; Stomach Neoplasms
Details
IBI-389IBI-389Phase 1 ClinicalEsophageal Neoplasms; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
FL-301NBL-015; FL-301Phase 1 ClinicalNovarock Biotherapeutics LtdPancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
IBI-360IBI-360Phase 1 ClinicalNeoplasms; Solid tumours
Details
QL-1779QL-1779; QL1779Phase 1 ClinicalQilu Pharmaceutical Co LtdSolid tumours
Details
LM-102LM-102Phase 1 ClinicalLaNova Medicines LtdBiliary Tract Neoplasms; Esophageal Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
HBM-1029HBM-1029; HBM1029Phase 1 ClinicalHarbour BiomedEsophageal Neoplasms; Solid tumours; Stomach Neoplasms
Details
LCAR-C18S CAR-T cell therapy (Legend)LB-1908; LCAR-C18S; LCAR-C-18-SPhase 1 ClinicalEsophageal Neoplasms; Gastroesophageal Junction Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
XKDCT-086XKDCT086; XKDCT-086ClinicalThe Affiliated Hospital Of Qingdao UniversityStomach Neoplasms
Details
CLDN18.2 UCAR-T cell therapyCLDN18.2 UCAR-TClinicalT-Maximum Pharmaceutical (Suzhou) Co LtdStomach Neoplasms
Details
124I-18B10124I-18B10; 124-I-18-B-10ClinicalBeijing Cancer Hospital, Transcenta Holding LtdGastrointestinal Neoplasms
Details
CTB-001(Nanjing Bioheng)CTB-001; CTB001ClinicalNanjing Bioheng Biotech Co LtdPancreatic Neoplasms; Stomach Neoplasms
Details
89Zr-NY00589Zr-NY005ClinicalWuxi Nuoyu Pharmaceutical Technology Co LtdPancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyEarliest Brand NameEarliest Approval CountryEarliest IndicationEarliest Approval CompanyEarliest Approval DateIndicationClinical Trial
ZolbetuximabGC-182; iMAB-362; IMAB-362ApprovedGanymedVyloy, VYLOY, 威络益JapanStomach NeoplasmsAstellas Pharma Inc2024-03-26Adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Lymphangioma, Cystic; Pain; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms
Details
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