CD74

CD74 Molekülinformation

Englischer Name	HLA-DR antigens-associated invariant chain	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5	Target-Alias	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	HLA-DR antigens-associated invariant chain
Target-Alias	CLIP，CD74，Ia antigen-associated invariant chain，CD74 Molecule，CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex， Class II Antigen-Associated)，CD74 Molecule， Major Histocompatibility Complex， Class II Invariant Chain，HLA-DR Antigens-Associated Invariant Chain，Ia-Associated Invariant Chain，MHC HLA-DR Gamma Chain，HLA-DR-Gamma，DHLAG，P33，CD74 Antigen，Ia-GAMMA，HLADG，II，Gamma Chain Of Class II Antigens，HLA Class II Histocompatibility Antigen Gamma Chain
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	5
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

CD74 Produktliste

Attribut
Protein (3)
Produktbibliothek
Online (3)
Spezies
Human (3)
Etikett
His Tag (1)Fc Tag (1)Llama IgG Fc Tag (1)
Marker
Unconjugated (3)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CD4-H524c	Human	HEK293	Human CD74 / DHLAG Protein, His Tag, low endotoxin (HPLC verified)	In den Warenkorb legen
CD4-H5256	Human	HEK293	Human CD74 / DHLAG Protein, Fc Tag (MALS verified)	In den Warenkorb legen
CD4-H5258	Human	HEK293	Human CD74 / DHLAG Protein, Llama IgG2b Fc Tag, low endotoxin	In den Warenkorb legen

Gesamtmenge3

CD74 Molekülhintergrund

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74 Molekülalias

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Influenza A M1 vaccine (Pascal Biosciences)		Phase 1 Clinical	Pascal Biosciences	Influenza A virus infections	Details
adenovector based vaccine (Pascal Biosciences/University of British Columbia)		Phase 1 Clinical	Nevis Brands Inc	Influenza A virus infections	Details
90Y-2IT-BAD-Lym-1	90Y-2IT-BAD-Lym-1	Phase 1 Clinical	National Cancer Institute	Lymphoma, Non-Hodgkin	Details
Bezetabart debotansine	STRO-001; SP7675; SP-7675; BN-301	Phase 1 Clinical	Sutro Biopharma Inc	Hematologic Neoplasms; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Multiple Myeloma	Details
TROP-2-targeted anti-CD74 siRNA (Immunomedics)			Immunomedics Inc	Solid tumours	Details