CD206

CD206 Molekülinformation

Englischer Name	Macrophage mannose receptor 1	Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	2	Target-Alias	C-type lectin domain family 13 member D，CLEC13D，Macrophage mannose receptor 1-like protein 1，hMR，Macrophage mannose receptor 1，C-type lectin domain family 13 member D-like，CLEC13DL，MRC1L1，MRC1，Mannose Receptor C-Type 1，Mannose Receptor， C Type 1-Like 1，Human Mannose Receptor，MMR，Mannose Receptor， C Type 1，CD206 Antigen，BA541I19.1，CD206
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Macrophage mannose receptor 1
Target-Alias	C-type lectin domain family 13 member D，CLEC13D，Macrophage mannose receptor 1-like protein 1，hMR，Macrophage mannose receptor 1，C-type lectin domain family 13 member D-like，CLEC13DL，MRC1L1，MRC1，Mannose Receptor C-Type 1，Mannose Receptor， C Type 1-Like 1，Human Mannose Receptor，MMR，Mannose Receptor， C Type 1，CD206 Antigen，BA541I19.1，CD206
Anzahl der inverkehr gebrachten Arzneimittel	1
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Approved

CD206 Produktliste

Attribut
Protein (7)
Produktbibliothek
Online (7)
Spezies
Human (3)Mouse (2)Cynomolgus (2)
Etikett
His Tag (4)His Tag & Avi Tag (3)
Marker
Unconjugated (3)Biotin-labeled (4)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CD6-H52H9	Human	HEK293	Human CD206 / MMR Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
HOT CD6-H82E4	Human	HEK293	Biotinylated Human CD206 / MMR Protein, His,Avitag™	In den Warenkorb legen
HOT CD6-H82H6	Human	HEK293	Biotinylated Human CD206 / MMR Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)	In den Warenkorb legen
HOT CD6-M52H7	Mouse	HEK293	Mouse CD206 / MMR Protein, His Tag (HPLC verified)	In den Warenkorb legen
CD6-M82E8	Mouse	HEK293	Biotinylated Mouse CD206 / MMR Protein, His,Avitag™ (HPLC verified)	In den Warenkorb legen
CD6-C52H7	Cynomolgus	HEK293	Cynomolgus CD206 / MMR Protein, His Tag (MALS verified)	In den Warenkorb legen
CD6-C82E4	Cynomolgus	HEK293	Biotinylated Cynomolgus CD206 / MMR Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen

Gesamtmenge7

CD206 Molekülhintergrund

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

CD206 Molekülalias

MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
68Ga-tilmanocept		Phase 3 Clinical	Navidea Biopharmaceuticals Inc	Atherosclerosis; Carcinoma, Endometrioid; Endometrial Neoplasms; Tuberculosis	Details
68GaNOTA-Anti-MMR-VHH2		Phase 2 Clinical	Universitair Ziekenhuis Brussel	Atherosclerosis; Carcinoma, Non-Small-Cell Lung; Carotid Stenosis; Hodgkin Disease; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoidosis	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Technetium Tc 99m tilmanocept	NEO3-09	Approved	University Of California	Lymphoseek Kit, Lymphoseek, Lymphoaim	United States	Solid tumours; Diagnostic agents; Breast Neoplasms; Melanoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms	Cardinal Health 414 Llc	2013-03-13	Anus Neoplasms; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Diagnostic agents; Endometrial Neoplasms; Head and Neck Neoplasms; HIV Infections; Liver Neoplasms; Melanoma; Metabolic Dysfunction-Associated Steatotic Liver Disease; Rectal Neoplasms; Sarcoidosis; Sarcoma, Kaposi; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms	Details