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Human Tyk2 Protein, His Tag

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Product Number/Spec
Price
Menge
TY2-H5548-100ug
$310.00
TY2-H5548-1mg
$2040.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    Tyk2, tyrosine kinase 2

  • Source

    Human Tyk2 Protein, His Tag (TY2-H5548) is expressed from Baculovirus-Insect cells. It contains AA Asn 575 - Leu 869 (Accession # P29597-1).

    Predicted N-terminus: His

    Request for sequence
  • Molecular Characterization

    Tyk2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 35.2 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    Tyk2 SDS-PAGE

    Human Tyk2 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

User Reviews
Publish Comment

Background Introduction

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Tyrosine-protein kinase 2

  • Category:

  • Listed Drugs Count:

    3 Details

  • Clinical Drugs Count:

    47 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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