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Rabbit TROP-2 / TACSTD2 Protein, His Tag (MALS verified)

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Product Number/Spec
Price
Menge
TR2-R52H9-100ug
$360.00
TR2-R52H9-1mg (500ug X 2)
$2380.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    TACSTD2, GA733-1, M1S1, TROP2

  • Source

    Rabbit TROP-2, His Tag (TR2-R52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 35 - Pro 279 (Accession # G1T6B6-1).

    Predicted N-terminus: Gln 35

    Request for sequence
  • Molecular Characterization

    TROP-2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 29.5 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    TROP-2 SDS-PAGE

    Rabbit TROP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    TROP-2 SEC-MALS

    The purity of Rabbit TROP-2, His Tag (Cat. No. TR2-R52H9) is more than 90% and the molecular weight of this protein is around 32-42 kDa verified by SEC-MALS.

    Report

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Publish Comment

Background Introduction

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Tumor-associated calcium signal transducer 2

  • Category:

  • Listed Drugs Count:

    3 Details

  • Clinical Drugs Count:

    47 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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