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Product Details
Synonyms
TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5
Source
Human TGF-beta RI Protein, Llama IgG2b Fc Tag (TG1-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 34 - Leu 126 (Accession # P36897-1).
Predicted N-terminus: Leu 34
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a llama IgG2b Fc tag at the C-terminus.
The protein has a calculated MW of 38.0 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Data Display
SDS-PAGE
Human TGF-beta RI Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
Bioactivity-SPR
Biotinylated Human TGF-Beta 1, Avitag (Cat. No. TG1-H8217) immobilized on SA Chip can bind Human TGF-beta RI, Llama IgG2b Fc Tag (Cat. No. TG1-H5259) with an affinity constant of 83.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
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Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Transforming growth factor beta receptor 1
- Category：
- Listed Drugs Count：
0 Details
- Clinical Drugs Count：
7 Details
- Highest R&D Stage：
Phase 3 Clinical
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