Human SHP-2 Protein, His Tag

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SH2-H5248-100ug
$390.00
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SH2-H5248-1mg (500ug X 2)
$3,500.00
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SH2-H5248
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Synonyms

SHP-2

Source

Human SHP-2, His Tag (SH2-H5248) is expressed from E. coli cells. It contains AA Thr 2 - Arg 593 (Accession # Q06124-2).

Predicted N-terminus: His

Molecular Characterization

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 69.3 kDa. The protein migrates as 65-66 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.

Background Introduction

SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. SHP-2 takes key role in transducing signal relay from the cell surface to the nucleus, and is a important intracellular regulator in mediating cell proliferation and differentiation.