Human SCARB2 / SR-B2 / LIMPII Protein, Fc Tag

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Cat. No. / Size
Price
Qty
SC2-H5250-100ug
$260.00
SC2-H5250-1mg (500ug X 2)
$1625.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    SCARB2, CD36L2, LIMP2, LIMPII

  • Source

    Human SCARB2, Fc Tag (SC2-H5250) is expressed from human 293 cells (HEK293). It contains AA Arg 27 - Thr 432 (Accession # AAH21892).

    Predicted N-terminus: Arg 27

    Request for sequence
  • Molecular Characterization

    SCARB2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 72.6 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    SCARB2 SDS-PAGE

    Human SCARB2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.

  • Bioactivity-ELISA

     SCARB2 ELISA

    Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 μg/mL (100 μL/well) can bind Human SCARB2, Fc Tag (Cat. No. SC2-H5250) with a linear range of 0.02-1.25 μg/mL (Routinely tested).

    Protocol

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Background

Scavenger receptor class B member 2 (SCARB2) is also known as Lysosome membrane protein 2 (LIMP2), 85 kDa lysosomal membrane sialoglycoprotein (LGP85), CD36 antigen-like 2 (CD36L2, LIMP2), which belongs to the CD36 family. SCARB2 acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.

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