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Human ROR2 / NTRKR2 Protein, Fc Tag (MALS verified)

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Product Number/Spec
Price
Menge
RO2-H5251-50ug
$300.00
RO2-H5251-1mg
$2245.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    ROR2, NTRKR2

  • Source

    Human ROR2, Fc Tag (RO2-H5251) is expressed from human 293 cells (HEK293). It contains AA Glu 34 - Gly 403 (Accession # A1L4F5-1).

    Predicted N-terminus: Glu 34

    Request for sequence
  • Molecular Characterization

    ROR2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 68 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    ROR2 SDS-PAGE

    Human ROR2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    ROR2 SEC-MALS

    The purity of Human ROR2, Fc Tag (Cat. No. RO2-H5251) is more than 85% and the molecular weight of this protein is around 140-175 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     ROR2 ELISA

    Immobilized Human ROR2, Fc Tag (Cat. No. RO2-H5251) at 1 μg/mL (100 μL/well) can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 2-8 ng/mL (QC tested).

    Protocol

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Publish Comment

Background Introduction

Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Tyrosine-protein kinase transmembrane receptor ROR2

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    1 Details

  • Highest R&D Stage:

    Phase 2 Clinical

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