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Mouse PTK7 / CCK4 Protein, Fc Tag (MALS verified)

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Product Number/Spec
Price
Menge
PT7-M5256-100ug
$360.00
PT7-M5256-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    PTK7, CCK4, CCK-4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7

  • Source

    Mouse PTK7 Protein, Fc Tag (PT7-M5256) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Thr 696 (Accession # Q8BKG3-1).

    Predicted N-terminus: Ala 23

    Request for sequence
  • Molecular Characterization

    PTK7 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 101.0 kDa. The protein migrates as 130-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    PTK7 SDS-PAGE

    Mouse PTK7 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    PTK7 SEC-MALS

    The purity of Mouse PTK7 Protein, Fc Tag (Cat. No. PT7-M5256) is more than 90% and the molecular weight of this protein is around 240-270 kDa verified by SEC-MALS.

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Publish Comment

Background Introduction

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Protein-tyrosine kinase 7

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    8 Details

  • Highest R&D Stage:

    Phase 2 Clinical

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