Human P-Selectin / CD62P Protein, His Tag

Customer Reviews
Cat. No. / Size
Price
Qty
SEP-H52E4-100ug
$285.00
SEP-H52E4-1mg (250ug X 4)
$1815.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    P-Selectin, CD62P, SELP, GMP-140

  • Source

    Human P-Selectin, His Tag (SEP-H52E4) is expressed from human 293 cells (HEK293). It contains AA Trp 42 - Ala 771 (Accession # AAN06828).

    Predicted N-terminus: Trp 42

    Request for sequence
  • Molecular Characterization

    P-Selectin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 81.8 kDa. The protein migrates as 110-125 kD under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    P-Selectin SDS-PAGE

    Human P-Selectin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Customer Reviews
Writing Reviews

  • V***u2023-07-13
    Likes
    AcroBio is our go to vendor, for our growing biotechnology start up. The customer service at acro bio is excellent, products have never failed in our labs. The specific product we got is the Human P-selectin/CD62P Protein His Tag which our lab has gotten multiple times and has not failed us. Thank you AcroBio for your amazing services, we appreciate you!

Background

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

Recent Advances

 
Drug Development Progress
  • English Name:

    P-selectin

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Approved

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